ago4 argonaute RISC component 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ago4provided by ZNC
Official Full Name: argonaute RISC component 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5357
See related: Ensembl:ENSDARG00000100854 AllianceGenome:ZFIN:ZDB-GENE-030131-5357
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: eif2c4; fd14f04; wu:fd14f04
Summary: Predicted to enable RNA endonuclease activity; miRNA binding activity; and single-stranded RNA binding activity. Predicted to be involved in pre-miRNA processing and regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to act upstream of or within regulation of translation and regulatory ncRNA-mediated gene silencing. Predicted to be located in P-body. Predicted to be part of RISC complex. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Is expressed in several structures, including eye; fin; integument; pleuroperitoneal region; and somite. Orthologous to human AGO4 (argonaute RISC component 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 19

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (47800698..47832853, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (48104215..48127173)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fc58c01.y1 (e-PCR)
- UniSTS:194114

fd14f04.x1 (e-PCR)
- UniSTS:204175

fj41g05.y1 (e-PCR)
- UniSTS:199317

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables miRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables miRNA binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in miRNA-mediated gene silencing by inhibition of translation	IEA Inferred from Electronic Annotation more info
involved_in pre-miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in P-body	IEA Inferred from Electronic Annotation more info
part_of RISC complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic ribonucleoprotein granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: protein argonaute-4

Names: argonaute 4; argonaute RISC catalytic component 4; eukaryotic translation initiation factor 2C, 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252559.2 → NP_001239488.1 protein argonaute-4

See identical proteins and their annotated locations for NP_001239488.1

Status: VALIDATED

Source sequence(s)

JX448395

UniProtKB/TrEMBL

A0A0R4IAN2, A0A8M1NZB7, K4IAH1

Related

ENSDARP00000131528.2, ENSDART00000170988.2

Conserved Domains (4) summary

cd02846
Location:219 → 339

PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...

cd04657
Location:386 → 821

Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...

pfam08699
Location:168 → 218

ArgoL1; Argonaute linker 1 domain

pfam16486
Location:28 → 157

ArgoN; N-terminal domain of argonaute