sirt6 sirtuin 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sirt6provided by ZNC
Official Full Name: sirtuin 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-031007-2
See related: Ensembl:ENSDARG00000102963 AllianceGenome:ZFIN:ZDB-GENE-031007-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:86729
Summary: Predicted to enable several functions, including NAD+ binding activity; NAD+-protein-arginine ADP-ribosyltransferase activity; and NAD-dependent protein lysine deacetylase activity. Is expressed in liver and retina. Orthologous to human SIRT6 (sirtuin 6). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: suggests misassembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (53065039..53201840, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (53469010..53532932, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables NAD+-protein-arginine ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD-dependent protein lysine deacetylase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 deacetylase activity, NAD-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NAD-dependent protein deacylase sirtuin-6

NP_001002071.1

EC 2.4.2.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002071.1 → NP_001002071.1 NAD-dependent protein deacylase sirtuin-6

See identical proteins and their annotated locations for NP_001002071.1

Status: PROVISIONAL

Source sequence(s)

BC071405

UniProtKB/TrEMBL

A0A8M9Q7D3, Q6IQK0

Related

ENSDARP00000134988.2, ENSDART00000163115.2

Conserved Domains (1) summary

cd01410
Location:46 → 257

SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...