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    ESR1 estrogen receptor 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 407238, updated on 1-Jan-2025

    Summary

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    Official Symbol
    ESR1provided by VGNC
    Official Full Name
    estrogen receptor 1provided by VGNC
    Primary source
    VGNC:VGNC:53791
    See related
    Ensembl:ENSBTAG00000007159
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ESR1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 9 NC_037336.1 (88683065..89098964)

    Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene myosin IC heavy chain Neighboring gene acidic residue methyltransferase 1 Neighboring gene coiled-coil domain containing 170 Neighboring gene uncharacterized LOC112448082 Neighboring gene uncharacterized LOC132346138 Neighboring gene spectrin repeat containing nuclear envelope protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Expression of estrogen and androgen receptor in the bovine gastrointestinal tract. Sauerwein H, et al. Dtsch Tierarztl Wochenschr, 1995 Apr. PMID 7555698
    2. Expression and localisation of oestrogen and progesterone receptors in the bovine mammary gland during development, function and involution. Schams D, et al. J Endocrinol, 2003 May. PMID 12740019
    3. Expression in promoter variant of the ERalpha gene in bos taurus liver. Szreder T, et al. Mol Biol Rep, 2008 Mar. PMID 17661161
    4. Distribution of estrogen receptor α and progesterone receptor B in the bovine oviduct during the follicular and luteal phases of the sexual cycle: an immunohistochemical and semi-quantitative study. Saruhan BG, et al. Biotech Histochem, 2011 Oct. PMID 20629585
    5. Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1). Derecka K, et al. Biochemistry, 2010 Sep 7. PMID 20715834

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Missing Information from the Estrogen Receptor Puzzle: Where Are They Localized in Bull Reproductive Tissues and Spermatozoa?
      Title: Missing Information from the Estrogen Receptor Puzzle: Where Are They Localized in Bull Reproductive Tissues and Spermatozoa?
    2. our results here suggest that there is a negative correlation between bta-miR-222 and ER-alpha expression during follicular development in cow ovaries.
      Title: Investigation of the interaction between bta-miR-222 and the estrogen receptor alpha gene in the bovine ovarium.
    3. The mRNA expression of ER-alpha and ER-beta in the hypothalamus of developing male and female bovines, is reported.
      Title: Gene expression profiles of estrogen receptors α and β in the fetal bovine hypothalamus and immunohistochemical characterization during development.
    4. Distribution of estrogen receptor alpha and progesterone receptor B in the bovine oviduct during the follicular and luteal phases of the sexual cycle: an immunohistochemical and semi-quantitative study
      Title: Distribution of estrogen receptor α and progesterone receptor B in the bovine oviduct during the follicular and luteal phases of the sexual cycle: an immunohistochemical and semi-quantitative study.
    5. ER-alpha is detected predominantly in the soma whereas ER-beta is only present in the nucleus of a few cells in the frontal cortex.
      Title: Expression and localization of aromatase P450AROM, estrogen receptor-α, and estrogen receptor-β in the developing fetal bovine frontal cortex.
    6. Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1
      Title: Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1).
    7. fetal ovary of cattle has the steroidogenic enzyme aromatase to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary
      Title: Morphological development and characterization of aromatase and estrogen receptors alpha and beta in fetal ovaries of cattle from days 110 to 250.
    8. estrogen receptor alpha amounts within the intercaruncular uterine wall do not change during the peripartal period
      Title: Progesterone receptors, oestrogen receptor alpha and glucocorticoid receptors in the bovine intercaruncular uterine wall around parturition.
    9. Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells.
      Title: Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells.
    10. The specific mRNA expression of ERalpha in various genotypes using real-time RT-PCR, was examined.
      Title: Expression in promoter variant of the ERalpha gene in bos taurus liver.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables estrogen response element binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear estrogen receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to estrogen stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in estrogen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    estrogen receptor
    Names
    ER
    ER-alpha
    estradiol receptor
    estrogen receptor alpha
    nuclear receptor subfamily 3 group A member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001443.1 → NP_001001443.1  estrogen receptor

      See identical proteins and their annotated locations for NP_001001443.1

      Status: PROVISIONAL

      Source sequence(s)
      AY538775
      UniProtKB/Swiss-Prot
      P49884, Q6QIS5, Q95131
      Related
      ENSBTAP00000009422.6, ENSBTAT00000009422.6
      Conserved Domains (4) summary
      cd06949
      Location:311 → 548
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:181 → 262
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42 → 182
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:557 → 596
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037336.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      88683065..89098964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024996420.2 → XP_024852188.1  estrogen receptor isoform X1

      UniProtKB/Swiss-Prot
      P49884, Q6QIS5, Q95131
      Conserved Domains (4) summary
      cd06949
      Location:311 → 548
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:181 → 262
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42 → 182
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:557 → 596
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49884.3 GenPept UniProtKB/Swiss-Prot:P49884

    Gene LinkOut

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