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    RPL34 ribosomal protein L34 [ Homo sapiens (human) ]

    Gene ID: 6164, updated on 27-Nov-2024

    Summary

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    Official Symbol
    RPL34provided by HGNC
    Official Full Name
    ribosomal protein L34provided by HGNC
    Primary source
    HGNC:HGNC:10340
    See related
    Ensembl:ENSG00000109475 MIM:616862; AllianceGenome:HGNC:10340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L34; eL34
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L34E family of ribosomal proteins. It is located in the cytoplasm. This gene originally was thought to be located at 17q21, but it has been mapped to 4q. Overexpression of this gene has been observed in some cancer cells. Alternative splicing results in multiple transcript variants, all encoding the same isoform. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Feb 2016]
    Expression
    Ubiquitous expression in ovary (RPKM 324.7), bone marrow (RPKM 227.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RPL34 in Genome Data Viewer
    Location:
    4q25
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (108620576..108630484)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (111923483..111933392)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (109541732..109551640)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene exocyst complex component 7-like Neighboring gene EXOC7 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21797 Neighboring gene RPL34 divergent transcript Neighboring gene uncharacterized LOC101929621 Neighboring gene VISTA enhancer hs1050 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:109541270-109542469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:109574151-109574665 Neighboring gene RNA, U6 small nuclear 431, pseudogene Neighboring gene oligosaccharyltransferase complex non-catalytic subunit Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:109634746-109635604 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:109635605-109636463 Neighboring gene ethanolamine-phosphate phospho-lyase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RNAi-mediated RPL34 knockdown suppresses the growth of human gastric cancer cells. Liu H, et al. Oncol Rep, 2015 Nov. PMID 26323242, Free PMC Article
    2. Over-expressed RPL34 promotes malignant proliferation of non-small cell lung cancer cells. Yang S, et al. Gene, 2016 Jan 15. PMID 26526135
    3. Ribosomal protein L34 promotes the proliferation, invasion and metastasis of pancreatic cancer cells. Wei F, et al. Oncotarget, 2016 Dec 20. PMID 27845896, Free PMC Article
    4. RPL34-AS1-induced RPL34 inhibits cervical cancer cell tumorigenesis via the MDM2-P53 pathway. Zhu Y, et al. Cancer Sci, 2021 May. PMID 33675124, Free PMC Article
    5. Highly expressed ribosomal protein L34 indicates poor prognosis in osteosarcoma and its knockdown suppresses osteosarcoma proliferation probably through translational control. Luo S, et al. Sci Rep, 2016 Nov 24. PMID 27883047, Free PMC Article

    See all (193) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RPL34-AS1-induced RPL34 inhibits cervical cancer cell tumorigenesis via the MDM2-P53 pathway.
      Title: RPL34-AS1-induced RPL34 inhibits cervical cancer cell tumorigenesis via the MDM2-P53 pathway.
    2. Findings indicated that knockdown of RPL34 inhibits the proliferation and migration of glioma cells through the inactivation of JAK/STAT3 signaling pathway.
      Title: Knockdown of RPL34 inhibits the proliferation and migration of glioma cells through the inactivation of JAK/STAT3 signaling pathway.
    3. The present study combines an individual-based phenotypic profiling with a transdiagnostic approach and shows that several ribosomal genes including RPL34 is involved in stress vulnerability across nonclinical and clinical conditions.
      Title: Integrated profiling of phenotype and blood transcriptome for stress vulnerability and depression.
    4. The RPL34 gene was highly expressed in OSCC, while silencing RPL34 could block cell proliferation and metastasis, but promote cell apoptosis, suggesting the RPL34 gene to be a new promising clinical target for OSCC therapy.
      Title: Influence of the RPL34 gene on the growth and metastasis of oral squamous cell carcinoma cells.
    5. RPL34 plays an important role in the proliferation of osteosarcoma cells.
      Title: Highly expressed ribosomal protein L34 indicates poor prognosis in osteosarcoma and its knockdown suppresses osteosarcoma proliferation probably through translational control.
    6. RPL34 functions as an oncogene that modulates the proliferation and metastasis of esophageal cancer cells in part through the inactivation of the PI3K/Akt signaling pathway
      Title: Silencing of Ribosomal Protein L34 (RPL34) Inhibits the Proliferation and Invasion of Esophageal Cancer Cells.
    7. this study shows that ribosomal protein L34 promotes the proliferation, invasion and metastasis of pancreatic cancer cells
      Title: Ribosomal protein L34 promotes the proliferation, invasion and metastasis of pancreatic cancer cells.
    8. RPL34 plays a critical role in cell proliferation, cell cycle distribution and apoptosis of human malignant gastric cells.
      Title: RNAi-mediated RPL34 knockdown suppresses the growth of human gastric cancer cells.
    9. over-expressed RPL34 may promote malignant proliferation of NSCLC cells, thus playing an important role in development and progress of NSCLC
      Title: Over-expressed RPL34 promotes malignant proliferation of non-small cell lung cancer cells.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag interacts with RPL34 as demonstrated by proximity dependent biotinylation proteomics PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC111005

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables cadherin binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit HDA PubMed 
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL34
    Names
    60S ribosomal protein L34
    leukemia-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000995.5 → NP_000986.2  large ribosomal subunit protein eL34

      See identical proteins and their annotated locations for NP_000986.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1-6 all encode the same protein.
      Source sequence(s)
      BC106009, BM971961
      Consensus CDS
      CCDS3680.1
      UniProtKB/Swiss-Prot
      P49207, Q6FG66, Q9BUZ2
      Conserved Domains (1) summary
      pfam01199
      Location:1 → 96
      Ribosomal_L34e; Ribosomal protein L34e

    2. NM_001319232.2 → NP_001306161.1  large ribosomal subunit protein eL34

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in its 5' and 3' UTRs compared to variant 2. Variants 1-6 all encode the same protein.
      Source sequence(s)
      AA128015, AA128058, AC084209, CD175155, DA779124
      Consensus CDS
      CCDS3680.1
      UniProtKB/Swiss-Prot
      P49207, Q6FG66, Q9BUZ2
      Related
      ENSP00000423316.1, ENST00000506397.5
      Conserved Domains (1) summary
      pfam01199
      Location:1 → 96
      Ribosomal_L34e; Ribosomal protein L34e

    3. NM_001319234.1 → NP_001306163.1  large ribosomal subunit protein eL34

      Status: REVIEWED

      Source sequence(s)
      CB132938, DA779124
      Consensus CDS
      CCDS3680.1
      UniProtKB/Swiss-Prot
      P49207, Q6FG66, Q9BUZ2
      Conserved Domains (1) summary
      pfam01199
      Location:1 → 96
      Ribosomal_L34e; Ribosomal protein L34e

    4. NM_001319235.2 → NP_001306164.1  large ribosomal subunit protein eL34

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in its 5' and 3' UTRs compared to variant 2. Variants 1-6 all encode the same protein.
      Source sequence(s)
      AC084209, BE394007, CD175155, DA779124
      Consensus CDS
      CCDS3680.1
      UniProtKB/Swiss-Prot
      P49207, Q6FG66, Q9BUZ2
      Related
      ENSP00000378160.1, ENST00000394665.5
      Conserved Domains (1) summary
      pfam01199
      Location:1 → 96
      Ribosomal_L34e; Ribosomal protein L34e

    5. NM_001319236.2 → NP_001306165.1  large ribosomal subunit protein eL34

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in its 5' and 3' UTRs compared to variant 2. Variants 1-6 all encode the same protein.
      Source sequence(s)
      BC106009, DA779124
      Consensus CDS
      CCDS3680.1
      UniProtKB/Swiss-Prot
      P49207, Q6FG66, Q9BUZ2
      Related
      ENSP00000378162.3, ENST00000394667.8
      Conserved Domains (1) summary
      pfam01199
      Location:1 → 96
      Ribosomal_L34e; Ribosomal protein L34e

    6. NM_033625.4 → NP_296374.1  large ribosomal subunit protein eL34

      See identical proteins and their annotated locations for NP_296374.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. Variants 1-6 all encode the same protein.
      Source sequence(s)
      AC084209, BC001773, BM971961, CD175155
      Consensus CDS
      CCDS3680.1
      UniProtKB/Swiss-Prot
      P49207, Q6FG66, Q9BUZ2
      Related
      ENSP00000378163.2, ENST00000394668.3
      Conserved Domains (1) summary
      pfam01199
      Location:1 → 96
      Ribosomal_L34e; Ribosomal protein L34e

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      108620576..108630484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      111923483..111933392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49207.3 GenPept UniProtKB/Swiss-Prot:P49207

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