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    LYST lysosomal trafficking regulator [ Bos taurus (domestic cattle) ]

    Gene ID: 281072, updated on 1-Jan-2025

    Summary

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    Official Symbol
    LYSTprovided by VGNC
    Official Full Name
    lysosomal trafficking regulatorprovided by VGNC
    Primary source
    VGNC:VGNC:31115
    See related
    Ensembl:ENSBTAG00000016804
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CHS1
    Orthologs
    human mouse all
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    Genomic context

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    See LYST in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    60
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 28 NC_037355.1 (8378030..8554283, complement)

    Chromosome 28 - NC_037355.1Genomic Context describing neighboring genes Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene G protein subunit gamma 4 Neighboring gene transfer RNA arginine (anticodon CCU) Neighboring gene microRNA mir-11982 Neighboring gene U6 spliceosomal RNA Neighboring gene nidogen 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Chediak-Higashi syndrome mutation and genetic testing in Japanese black cattle (Wagyu). Yamakuchi H, et al. Anim Genet, 2000 Feb. PMID 10690356
    2. Cloning of bovine LYST gene and identification of a missense mutation associated with Chediak-Higashi syndrome of cattle. Kunieda T, et al. Mamm Genome, 1999 Dec. PMID 10594238
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lysosomal-trafficking regulator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174020.2 → NP_776445.1  lysosomal-trafficking regulator

      See identical proteins and their annotated locations for NP_776445.1

      Status: PROVISIONAL

      Source sequence(s)
      AF114785
      UniProtKB/Swiss-Prot
      O97699, Q9TTK4
      Related
      ENSBTAP00000022355.6, ENSBTAT00000022355.7
      Conserved Domains (5) summary
      smart01026
      Location:3127 → 3417
      Beach; Beige/BEACH domain
      COG2319
      Location:3471 → 3778
      WD40; WD40 repeat [General function prediction only]
      cd01201
      Location:3007 → 3112
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:3523 → 3560
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:3524 → 3773
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037355.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      8378030..8554283 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059882423.1 → XP_059738406.1  lysosomal-trafficking regulator isoform X1

      UniProtKB/Swiss-Prot
      O97699, Q9TTK4

    2. XM_059882412.1 → XP_059738395.1  lysosomal-trafficking regulator isoform X1

      UniProtKB/Swiss-Prot
      O97699, Q9TTK4

    3. XM_059882419.1 → XP_059738402.1  lysosomal-trafficking regulator isoform X1

      UniProtKB/Swiss-Prot
      O97699, Q9TTK4

    4. XM_059882416.1 → XP_059738399.1  lysosomal-trafficking regulator isoform X1

      UniProtKB/Swiss-Prot
      O97699, Q9TTK4

    5. XM_059882415.1 → XP_059738398.1  lysosomal-trafficking regulator isoform X1

      UniProtKB/Swiss-Prot
      O97699, Q9TTK4

    6. XM_059882420.1 → XP_059738403.1  lysosomal-trafficking regulator isoform X1

      UniProtKB/Swiss-Prot
      O97699, Q9TTK4

    7. XM_059882418.1 → XP_059738401.1  lysosomal-trafficking regulator isoform X1

      UniProtKB/Swiss-Prot
      O97699, Q9TTK4

    8. XM_059882422.1 → XP_059738405.1  lysosomal-trafficking regulator isoform X1

      UniProtKB/Swiss-Prot
      O97699, Q9TTK4

    9. XM_059882413.1 → XP_059738396.1  lysosomal-trafficking regulator isoform X1

      UniProtKB/Swiss-Prot
      O97699, Q9TTK4

    10. XM_059882428.1 → XP_059738411.1  lysosomal-trafficking regulator isoform X6

      UniProtKB/Swiss-Prot
      O97699, Q9TTK4

    11. XM_059882426.1 → XP_059738409.1  lysosomal-trafficking regulator isoform X4

      UniProtKB/Swiss-Prot
      O97699, Q9TTK4

    12. XM_059882424.1 → XP_059738407.1  lysosomal-trafficking regulator isoform X2

      UniProtKB/Swiss-Prot
      O97699, Q9TTK4

    13. XM_059882427.1 → XP_059738410.1  lysosomal-trafficking regulator isoform X5

      UniProtKB/Swiss-Prot
      O97699, Q9TTK4

    14. XM_059882425.1 → XP_059738408.1  lysosomal-trafficking regulator isoform X3

      UniProtKB/Swiss-Prot
      O97699, Q9TTK4

    15. XM_059882414.1 → XP_059738397.1  lysosomal-trafficking regulator isoform X1

      UniProtKB/Swiss-Prot
      O97699, Q9TTK4

    16. XM_059882421.1 → XP_059738404.1  lysosomal-trafficking regulator isoform X1

      UniProtKB/Swiss-Prot
      O97699, Q9TTK4

    17. XM_059882429.1 → XP_059738412.1  lysosomal-trafficking regulator isoform X7

      UniProtKB/Swiss-Prot
      O97699, Q9TTK4

    18. XM_059882430.1 → XP_059738413.1  lysosomal-trafficking regulator isoform X8

      UniProtKB/Swiss-Prot
      O97699, Q9TTK4

    19. XM_059882431.1 → XP_059738414.1  lysosomal-trafficking regulator isoform X9

      UniProtKB/Swiss-Prot
      O97699, Q9TTK4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TTK4.1 GenPept UniProtKB/Swiss-Prot:Q9TTK4

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