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    POLR3GL RNA polymerase III subunit GL [ Homo sapiens (human) ]

    Gene ID: 84265, updated on 10-Dec-2024

    Summary

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    Official Symbol
    POLR3GLprovided by HGNC
    Official Full Name
    RNA polymerase III subunit GLprovided by HGNC
    Primary source
    HGNC:HGNC:28466
    See related
    Ensembl:ENSG00000121851 MIM:617457; AllianceGenome:HGNC:28466
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SOFM; RPC32HOM; flj32422
    Summary
    Predicted to enable chromatin binding activity. Involved in transcription by RNA polymerase III. Located in nucleus. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in fat (RPKM 24.4), spleen (RPKM 14.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See POLR3GL in Genome Data Viewer
    Location:
    1q21.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (145964690..145978848)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (145081507..145095672)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145456236..145470400, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene LIX1L antisense RNA 1 Neighboring gene limb and CNS expressed 1 like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1269 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1270 Neighboring gene conserved acetylation island sequence C12 enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145473321-145474156 Neighboring gene Sharpr-MPRA regulatory region 4010 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1621 Neighboring gene ankyrin repeat domain 34A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145458517-145459016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1622 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:145455010-145456209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1628 Neighboring gene thioredoxin interacting protein Neighboring gene ReSE screen-validated silencer GRCh37_chr1:145432616-145432823 Neighboring gene hemojuvelin BMP co-receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structural insights into transcriptional regulation of human RNA polymerase III. Wang Q, et al. Nat Struct Mol Biol, 2021 Feb. PMID 33558766
    2. Effects on prostate cancer cells of targeting RNA polymerase III. Petrie JL, et al. Nucleic Acids Res, 2019 May 7. PMID 30820548, Free PMC Article
    3. Structure-function analysis of hRPC62 provides insights into RNA polymerase III transcription initiation. Lefèvre S, et al. Nat Struct Mol Biol, 2011 Mar. PMID 21358628
    4. Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation. Haurie V, et al. Proc Natl Acad Sci U S A, 2010 Mar 2. PMID 20154270, Free PMC Article
    5. Gene duplication and neofunctionalization: POLR3G and POLR3GL. Renaud M, et al. Genome Res, 2014 Jan. PMID 24107381, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Short stature, oligodontia, dysmorphic facies, and motor delay
    MedGen: C5543206 OMIM: 619234 GeneReviews: Not available
    		not available

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC3200, FLJ34890

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase III subunit RPC7-like
    Names
    DNA-directed RNA polymerase III subunit G-like
    RNA polymerase III 32 kDa beta subunit
    RNA polymerase III subunit C7-like
    RNA polymerase III subunit G like
    RPC32-beta
    RPC32-like protein
    alternative RNA polymerase III subunit 32
    polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like
    polymerase (RNA) III subunit G like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330685.2 → NP_001317614.1  DNA-directed RNA polymerase III subunit RPC7-like isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC004355, BI914801, CN261802
      Consensus CDS
      CCDS81367.1
      UniProtKB/TrEMBL
      A6NGX6
      Related
      ENSP00000358319.3, ENST00000369313.7
      Conserved Domains (1) summary
      pfam11705
      Location:16 → 192
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

    2. NM_032305.3 → NP_115681.1  DNA-directed RNA polymerase III subunit RPC7-like isoform 1

      See identical proteins and their annotated locations for NP_115681.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC004355, BI914801
      Consensus CDS
      CCDS72875.1
      UniProtKB/Swiss-Prot
      B1MVG5, Q9BT43
      Related
      ENSP00000358320.1, ENST00000369314.2
      Conserved Domains (1) summary
      pfam11705
      Location:16 → 204
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      145964690..145978848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      145081507..145095672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BT43.1 GenPept UniProtKB/Swiss-Prot:Q9BT43

    Gene LinkOut

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