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    arih2 ariadne homolog 2 (Drosophila) [ Danio rerio (zebrafish) ]

    Gene ID: 406417, updated on 9-Dec-2024

    Summary

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    Official Symbol
    arih2provided by ZNC
    Official Full Name
    ariadne homolog 2 (Drosophila)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2158
    See related
    Ensembl:ENSDARG00000012848 AllianceGenome:ZFIN:ZDB-GENE-040426-2158
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:64093; wu:fa09c12
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within protein ubiquitination. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See arih2 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (26034616..26057401)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (26015428..26038262)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene microRNA 135b Neighboring gene xeroderma pigmentosum, complementation group C Neighboring gene IMP (inosine 5'-monophosphate) dehydrogenase 2 Neighboring gene microRNA 462

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of amacrine subtypes that express the atypical cadherin celsr3. Lewis AA, et al. Exp Eye Res, 2015 Jan. PMID 25479044, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase ARIH2
    NP_998308.1
    XP_009302263.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213143.1 → NP_998308.1  E3 ubiquitin-protein ligase ARIH2

      See identical proteins and their annotated locations for NP_998308.1

      Status: PROVISIONAL

      Source sequence(s)
      BC053248
      UniProtKB/TrEMBL
      A0A8M1PNX8, Q7T355
      Related
      ENSDARP00000011198.8, ENSDART00000004521.10
      Conserved Domains (2) summary
      smart00647
      Location:199 → 261
      IBR; In Between Ring fingers
      pfam01485
      Location:289 → 321
      IBR; IBR domain, a half RING-finger domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      26034616..26057401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009303988.4 → XP_009302263.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

      See identical proteins and their annotated locations for XP_009302263.1

      UniProtKB/TrEMBL
      A0A8M1PNX8, Q7T355
      Conserved Domains (2) summary
      smart00647
      Location:199 → 261
      IBR; In Between Ring fingers
      pfam01485
      Location:289 → 321
      IBR; IBR domain, a half RING-finger domain
    Nucleotide Protein Strain
    Heading Accession and Version

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