hip1 huntingtin interacting protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hip1provided by ZNC
Official Full Name: huntingtin interacting protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-010328-15
See related: Ensembl:ENSDARG00000062972 AllianceGenome:ZFIN:ZDB-GENE-010328-15
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb98d04; wu:fb98d04
Summary: Predicted to enable several functions, including anion binding activity; clathrin adaptor activity; and clathrin light chain binding activity. Acts upstream of or within chordate embryonic development and response to yeast. Predicted to be located in cytoplasm. Predicted to be active in clathrin-coated vesicle; cortical actin cytoskeleton; and presynapse. Orthologous to human HIP1 (huntingtin interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 15

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (16935390..17024779, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (17000111..17088823, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

G47440 (e-PCR)
- UniSTS:108218

fi33d04.x1 (e-PCR)
- UniSTS:197308

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin binding	IEA Inferred from Electronic Annotation more info
enables clathrin light chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in clathrin coat assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of platelet-derived growth factor receptor-beta signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to yeast	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in clathrin-coated vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in presynapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: huntingtin-interacting protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166205.2 → NP_001159677.1 huntingtin-interacting protein 1

See identical proteins and their annotated locations for NP_001159677.1

Status: PROVISIONAL

Source sequence(s)

AB494966

UniProtKB/TrEMBL

C9K4U5

Related

ENSDARP00000127621.1, ENSDART00000154719.3

Conserved Domains (5) summary

smart00307
Location:836 → 1034

ILWEQ; I/LWEQ domain

pfam07651
Location:40 → 308

ANTH; ANTH domain

pfam15619
Location:378 → 557

Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

pfam16515
Location:483 → 581

HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

cl23720
Location:377 → 489

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

16935390..17024779 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005157432.5 → XP_005157489.1 huntingtin-interacting protein 1 isoform X1

UniProtKB/TrEMBL

A0A8M2B480, F1R6L2

Related

ENSDARP00000013812.10, ENSDART00000014465.10

Conserved Domains (5) summary

smart00307
Location:836 → 1034

ILWEQ; I/LWEQ domain

pfam07651
Location:40 → 308

ANTH; ANTH domain

pfam16515
Location:483 → 581

HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

pfam17045
Location:383 → 642

CEP63; Centrosomal protein of 63 kDa

cl23720
Location:377 → 489

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
XM_005157433.5 → XP_005157490.1 huntingtin-interacting protein 1 isoform X2

UniProtKB/TrEMBL

A0A8M2B3I8

Conserved Domains (5) summary

smart00307
Location:802 → 1000

ILWEQ; I/LWEQ domain

pfam07651
Location:7 → 274

ANTH; ANTH domain

pfam16515
Location:449 → 547

HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

pfam17045
Location:349 → 608

CEP63; Centrosomal protein of 63 kDa

cl23720
Location:343 → 455

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
XM_009291565.4 → XP_009289840.1 huntingtin-interacting protein 1 isoform X3

UniProtKB/TrEMBL

A0A8M3ASL4

Conserved Domains (5) summary

smart00307
Location:802 → 1000

ILWEQ; I/LWEQ domain

pfam00261
Location:385 → 592

Tropomyosin; Tropomyosin

pfam07651
Location:40 → 308

ANTH; ANTH domain

pfam16515
Location:483 → 595

HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

cl23720
Location:377 → 489

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)