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    CLCA1 chloride channel accessory 1 [ Homo sapiens (human) ]

    Gene ID: 1179, updated on 10-Dec-2024

    Summary

    Official Symbol
    CLCA1provided by HGNC
    Official Full Name
    chloride channel accessory 1provided by HGNC
    Primary source
    HGNC:HGNC:2015
    See related
    Ensembl:ENSG00000016490 MIM:603906; AllianceGenome:HGNC:2015
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CACC; GOB5; CACC1; CLCRG1; CaCC-1; hCLCA1; hCaCC-1
    Summary
    This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in small intestine (RPKM 634.9), duodenum (RPKM 392.5) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CLCA1 in Genome Data Viewer
    Location:
    1p22.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (86468927..86500259)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (86308943..86340288)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (86934610..86965942)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RPL7L1 pseudogene 22 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:86875355-86875998 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_9486 Neighboring gene chloride channel accessory 2 Neighboring gene uncharacterized LOC124904210 Neighboring gene uncharacterized LOC105378827 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1277 Neighboring gene NANOG hESC enhancer GRCh37_chr1:86973470-86973971 Neighboring gene uncharacterized LOC105378826

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 from both CCR5- and CXCR4-tropic HIV-1 strains opens calcium-activated potassium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages; these signals are mediated by CCR5 and CXCR4 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • FLJ95147

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chloride channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables intracellularly calcium-gated chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoatomic ion transmembrane transport TAS
    Traceable Author Statement
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microvillus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in zymogen granule membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    calcium-activated chloride channel regulator 1
    Names
    CLCA family member 1, chloride channel regulator
    calcium-activated chloride channel family member 1
    calcium-activated chloride channel protein 1
    calcium-dependent chloride channel-1
    chloride channel regulator 1
    chloride channel, calcium activated, family member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285.4NP_001276.3  calcium-activated chloride channel regulator 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AF127036, AL122002, DA428844
      Consensus CDS
      CCDS709.1
      UniProtKB/Swiss-Prot
      A8K7I4, B2RAV5, O95151, Q5TDF4, Q9UNF6, Q9UPC6
      Related
      ENSP00000378200.1, ENST00000394711.2
      Conserved Domains (1) summary
      TIGR00868
      Location:1861
      hCaCC; calcium-activated chloride channel protein 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      86468927..86500259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      86308943..86340288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)