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    rps12 ribosomal protein S12 [ Danio rerio (zebrafish) ]

    Gene ID: 337007, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rps12provided by ZNC
    Official Full Name
    ribosomal protein S12provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8951
    See related
    Ensembl:ENSDARG00000036875 AllianceGenome:ZFIN:ZDB-GENE-030131-8951
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa95a02; zgc:73055; wu:fa95a02
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in maintenance of translational fidelity and ribosomal small subunit biogenesis. Predicted to act upstream of or within translation. Predicted to be located in ribosome. Predicted to be part of cytosolic small ribosomal subunit. Orthologous to human RPS12 (ribosomal protein S12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rps12 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (31431956..31435923)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (31505425..31509392)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene si:dkeyp-79f12.7 Neighboring gene SH3 domain binding glutamate-rich protein like 2 Neighboring gene zgc:153284 Neighboring gene small nucleolar RNA SNORD101 Neighboring gene small nucleolar RNA SNORD100 Neighboring gene EYA transcriptional coactivator and phosphatase 4 Neighboring gene transcription factor 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Systematic identification of seven ribosomal protein genes in bighead carp and their expression in response to microcystin-LR. Cai Y, et al. J Toxicol Sci, 2016 Apr. PMID 26961614
    2. Many ribosomal protein genes are cancer genes in zebrafish. Amsterdam A, et al. PLoS Biol, 2004 May. PMID 15138505, Free PMC Article
    3. Oocyte-specific maternal Slbp2 is required for replication-dependent histone storage and early nuclear cleavage in zebrafish oogenesis and embryogenesis. He WX, et al. RNA, 2018 Dec. PMID 30185624, Free PMC Article
    4. An environmentally relevant mixture of polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDEs) disrupts mitochondrial function, lipid metabolism and neurotransmission in the brain of exposed zebrafish and their unexposed F2 offspring. Blanc M, et al. Sci Total Environ, 2021 Feb 1. PMID 32911150
    5. GLUT12 deficiency during early development results in heart failure and a diabetic phenotype in zebrafish. Jiménez-Amilburu V, et al. J Endocrinol, 2015 Jan. PMID 25326603

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maintenance of translational fidelity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein eS12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282177.1 → NP_001269106.1  small ribosomal subunit protein eS12

      See identical proteins and their annotated locations for NP_001269106.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BI326372, CT698501
      UniProtKB/TrEMBL
      F6NJU2, F6NXQ3, Q6PC90
      Related
      ENSDARP00000120403.1, ENSDART00000138350.3
      Conserved Domains (1) summary
      pfam01248
      Location:16 → 111
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

    2. NM_200046.3 → NP_956340.1  small ribosomal subunit protein eS12

      See identical proteins and their annotated locations for NP_956340.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BI326372, CR759830
      UniProtKB/TrEMBL
      F6NJU2, F6NXQ3, Q6PC90
      Related
      ENSDARP00000053541.5, ENSDART00000053542.6
      Conserved Domains (1) summary
      pfam01248
      Location:16 → 111
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      31431956..31435923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395159.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      272500..276432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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