Gnrhr gonadotropin releasing hormone receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gnrhrprovided by MGI
Official Full Name: gonadotropin releasing hormone receptorprovided by MGI
Primary source: MGI:MGI:95790
See related: Ensembl:ENSMUSG00000029255 AllianceGenome:MGI:95790
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable gonadotropin-releasing hormone receptor activity and growth hormone-releasing hormone receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cellular response to hormone stimulus; and negative regulation of cell population proliferation. Predicted to be active in plasma membrane. Is expressed in several structures, including adenohypophysis; jaw; mandibular process; and ovary. Used to study hypogonadotropic hypogonadism 7 with or without anosmia. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 7 with or without anosmia. Orthologous to human GNRHR (gonadotropin releasing hormone receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 5 E1; 5 43.56 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (86328613..86345760, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (86180754..86197901, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional GnRH receptor signaling regulates striatal cholinergic neurons in neonatal but not in adult mice.
Title: Functional GnRH receptor signaling regulates striatal cholinergic neurons in neonatal but not in adult mice.
AXL receptor tyrosine kinase modulates gonadotropin-releasing hormone receptor signaling.
Title: AXL receptor tyrosine kinase modulates gonadotropin-releasing hormone receptor signaling.
Activation of Gonadotropin-releasing Hormone Receptor Impedes the Immunosuppressive Activity of Decidual Regulatory T Cells via Deactivating the Mechanistic Target of Rapamycin Signaling.
Title: Activation of Gonadotropin-releasing Hormone Receptor Impedes the Immunosuppressive Activity of Decidual Regulatory T Cells via Deactivating the Mechanistic Target of Rapamycin Signaling.
Androgen receptor positively regulates gonadotropin-releasing hormone receptor in pituitary gonadotropes.
Title: Androgen receptor positively regulates gonadotropin-releasing hormone receptor in pituitary gonadotropes.
Fyn-mediated phosphorylation of Pyk2 promotes its activation and dissociation downstream of gonadotropin-releasing hormone receptor.
Title: Fyn-mediated phosphorylation of Pyk2 promotes its activation and dissociation downstream of gonadotropin-releasing hormone receptor.
GnRH Antagonists Produce Differential Modulation of the Signaling Pathways Mediated by GnRH Receptors.
Title: GnRH Antagonists Produce Differential Modulation of the Signaling Pathways Mediated by GnRH Receptors.
GnRH receptorexpression levels depend on JUN and are critical for reproductive function.
Title: GnRH Receptor Expression and Reproductive Function Depend on JUN in GnRH Receptor‒Expressing Cells.
leptin's direct stimulatory actions on gonadotrope GnRHR correlate with a direct inhibition of expression of the posttranscriptional regulator MSI1. There also is a direct MSI1 interaction with 3'-UTR of Gnrhr mRNA.
Title: Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression.
the age-dependent basal and regulated Gnrhr transcription could account for the initial blockade and subsequent activation of the reproductive system during development.
Title: The relationship between basal and regulated Gnrhr expression in rodent pituitary gonadotrophs.
GnRH-GnRHR system is not essential for growth or motor/sensory/orientation behavior during the first month of life prior to puberty onset. The lack of the GnRH-GnRHR axis, however, did affect females resulting in reduced subcutaneous inguinal fat pad weight and increased glucose with possible insulin resistance.
Title: Gonadotropin-releasing hormone receptor (Gnrhr) gene knock out: Normal growth and development of sensory, motor and spatial orientation behavior but altered metabolism in neonatal and prepubertal mice.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (4)
Gene trapped (1)
Targeted (6) 1 citation

General gene information

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Markers

L01119 (e-PCR)
- UniSTS:163363

Gnrhr (e-PCR), detects polymorphism
- UniSTS:166219

L33789 (e-PCR)
- UniSTS:124900

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables gonadotropin-releasing hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables gonadotropin-releasing hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables growth hormone-releasing hormone receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to gonadotropin-releasing hormone	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: gonadotropin-releasing hormone receptor

Names: gnRH receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310651.1 → NP_001297580.1 gonadotropin-releasing hormone receptor isoform 2

See identical proteins and their annotated locations for NP_001297580.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate coding exon, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter, distinct C-terminus compared to isoform 1.

Source sequence(s)

AC107634

Consensus CDS

CCDS80313.1

UniProtKB/TrEMBL

A0A192B0U8, D3Z6P7

Related

ENSMUSP00000108999.2, ENSMUST00000113372.2

Conserved Domains (1) summary

pfam00001
Location:76 → 174

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_001310653.1 → NP_001297582.1 gonadotropin-releasing hormone receptor isoform 3

See identical proteins and their annotated locations for NP_001297582.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks the 3' exon and its transcription extends past a splice site used in variant 1, resulting in a distinct 3' coding region and 3' UTR. The encoded isoform (3) has a distinct, shorter C-terminus compared to isoform 1.

Source sequence(s)

AC107634

Consensus CDS

CCDS84897.1

UniProtKB/TrEMBL

Q6P8H4

Related

ENSMUSP00000092238.3, ENSMUST00000094654.3

Conserved Domains (1) summary

pfam00001
Location:76 → 247

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_010323.2 → NP_034453.1 gonadotropin-releasing hormone receptor isoform 1

See identical proteins and their annotated locations for NP_034453.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC107634, L01119

Consensus CDS

CCDS19379.1

UniProtKB/Swiss-Prot

Q01776, Q61611

Related

ENSMUSP00000031172.9, ENSMUST00000031172.9

Conserved Domains (1) summary

pfam00001
Location:76 → 322

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

86328613..86345760 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017320667.1 → XP_017176156.1 gonadotropin-releasing hormone receptor isoform X1

Conserved Domains (2) summary

cd14964
Location:37 → 68

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:36 → 174

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily