Shal Shaker cognate l [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Shalprovided by FlyBase
Official Full Name: Shaker cognate lprovided by FlyBase
Primary source: FLYBASE:FBgn0005564
Locus tag: Dmel_CG9262
See related: AllianceGenome:FB:FBgn0005564
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9262; Dmel\CG9262; DNK[[v]]4; dShal; Kv4; Kv4/Shal; K[[v]]4; Sh-l; shaI; ShaI; shal; Shl
Summary: Enables A-type (transient outward) potassium channel activity. Involved in associative learning and chemical synaptic transmission. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in several structures, including adult head; embryonic hindgut; ganglia; larval muscle system; and larval visceral muscle cell. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Orthologous to several human genes including KCND3 (potassium voltage-gated channel subfamily D member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 76B7-76B8; 3-45 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (19566851..19584568, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (19559951..19577668, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study identified that Shal/Kv4, a well known voltage-gated K+ channel, acts as a controller of wake-sleep transition at dusk in Drosophila circadian neurons.
Title: Control of Sleep Onset by Shal/K(v)4 Channels in Drosophila Circadian Neurons.
We found that ddaE neurons have an axonal diffusion barrier proximal to the cell body that requires a giant isoform of the neuronal ankyrin Ank2. Furthermore, the potassium channel shal concentrates in the proximal axon in an Ank2-dependent manner
Title: Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment.
The loss of Shal potassium channel induces compensatory rebalancing of ion channel expression.
Title: Krüppel mediates the selective rebalancing of ion channel expression.
In Drosophila, the single Shal/K(v)4 gene encodes the predominant I(A) current in many neuronal cell bodies.
Title: Shal/K(v)4 channels are required for maintaining excitability during repetitive firing and normal locomotion in Drosophila.
Data show that SIDL is expressed primarily in the nervous system, co-localizes with GFP-Shal channels in neurons, and interacts specifically with the LL-motif of Drosophila and mouse Shal channels.
Title: SIDL interacts with the dendritic targeting motif of Shal (K(v)4) K+ channels in Drosophila.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables A-type (transient outward) potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables A-type (transient outward) potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	TAS Traceable Author Statement more info	PubMed
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	TAS Traceable Author Statement more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: shaker cognate l

Names: CG9262-PA; CG9262-PB; CG9262-PC; Shaker-like; Shal-PA; Shal-PB; Shal-PC; shaker cognate 1; shaker cognate L

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

19566851..19584568 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001104176.2 → NP_001097646.1 shaker cognate l, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097646.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A8JNV8, P17971, Q29R37, Q9VW11

Conserved Domains (3) summary

cd18420
Location:6 → 144

BTB_POZ_Shal-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins

pfam00520
Location:188 → 415

Ion_trans; Ion transport protein

pfam11879
Location:445 → 540

DUF3399; Domain of unknown function (DUF3399)
NM_001275126.1 → NP_001262055.1 shaker cognate l, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262055.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PFP1

Conserved Domains (3) summary

cd18420
Location:6 → 144

BTB_POZ_Shal-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins

pfam00520
Location:188 → 415

Ion_trans; Ion transport protein

pfam11879
Location:445 → 490

DUF3399; Domain of unknown function (DUF3399)
NM_079435.4 → NP_524159.1 shaker cognate l, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524159.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P17971

Related

FBpp0074741

Conserved Domains (3) summary

cd18420
Location:6 → 144

BTB_POZ_Shal-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins

pfam00520
Location:188 → 415

Ion_trans; Ion transport protein

pfam11879
Location:445 → 489

DUF3399; Domain of unknown function (DUF3399)