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    CG14073 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40046, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14073provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036814
    Locus tag
    Dmel_CG14073
    See related
    AllianceGenome:FB:FBgn0036814
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG14073; Nirvana
    Summary
    Predicted to enable transcription corepressor activity. Involved in wing disc dorsal/ventral pattern formation. Predicted to be active in nucleus. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in Shukla-Vernon syndrome; dental caries; eye disease (multiple); and gastrointestinal system cancer (multiple). Orthologous to several human genes including BCORL1 (BCL6 corepressor like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14073 in Genome Data Viewer
    Location:
    75E1-75E1; 3-45 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18802265..18820675, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18795365..18813775, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45938 Neighboring gene ftz transcription factor 1 Neighboring gene long non-coding RNA:CR45939 Neighboring gene HP1-HOAP-interacting protein Neighboring gene Catalase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Microarray-based capture of novel expressed cell type-specific transfrags (CoNECT) to annotate tissue-specific transcription in Drosophila melanogaster. Hong X, et al. G3 (Bethesda), 2012 Aug. PMID 22908036, Free PMC Article
    2. A gain-of-function suppressor screen for genes involved in dorsal-ventral boundary formation in the Drosophila wing. Bejarano F, et al. Genetics, 2008 Jan. PMID 18202376, Free PMC Article
    3. Fungal peptide Destruxin A plays a specific role in suppressing the innate immune response in Drosophila melanogaster. Pal S, et al. J Biol Chem, 2007 Mar 23. PMID 17227774
    4. The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis. Beckstead RB, et al. Genome Biol, 2005. PMID 16356271, Free PMC Article
    5. Variant Polycomb complexes in Drosophila consistent with ancient functional diversity. Kang H, et al. Sci Adv, 2022 Sep 9. PMID 36070387, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wing disc dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14073-PB
    CG14073-PC
    nirvana

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18802265..18820675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275093.1 → NP_001262022.1  uncharacterized protein Dmel_CG14073, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262022.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQT4
      Conserved Domains (4) summary
      cd00204
      Location:1697 → 1807
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14259
      Location:2016 → 2129
      PUFD_like; PCGF Ub-like fold discriminator and related domains
      pfam12796
      Location:1702 → 1790
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:1697 → 1728
      ANK; ANK repeat [structural motif]

    2. NM_140803.2 → NP_649060.1  uncharacterized protein Dmel_CG14073, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649060.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQT4
      Related
      FBpp0074851
      Conserved Domains (4) summary
      cd00204
      Location:1697 → 1807
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14259
      Location:2016 → 2129
      PUFD_like; PCGF Ub-like fold discriminator and related domains
      pfam12796
      Location:1702 → 1790
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:1697 → 1728
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQT4 Q8IQT4
    Q8MT12 Q8MT12

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