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    AstC-R2 Allatostatin C receptor 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40019, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AstC-R2provided by FlyBase
    Official Full Name
    Allatostatin C receptor 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0036789
    Locus tag
    Dmel_CG13702
    See related
    AllianceGenome:FB:FBgn0036789
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aicr2; AlCR-2; AlCR2; anon-WO0170980.154; anon-WO0170980.155; AstC R2; ASTC-R2; AstCR2; CG13702; Dmel\CG13702; Drostar2; lincRNA.610
    Summary
    Enables allatostatin receptor activity. Involved in neuropeptide signaling pathway. Located in plasma membrane. Is expressed in several structures, including adult brain; adult gut-innervating neurons; adult pars intercerebralis; lamina monopolar neurons; and larval central nervous system. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; drug dependence (multiple); drug psychosis; and withdrawal disorder (multiple). Orthologous to several human genes including SSTR2 (somatostatin receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AstC-R2 in Genome Data Viewer
    Location:
    75D1-75D1; 3-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18485137..18502557, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18478237..18495657, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44672 Neighboring gene long non-coding RNA:CR44673 Neighboring gene uncharacterized protein Neighboring gene Allatostatin C receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Silencing preBötzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat. Tan W, et al. Nat Neurosci, 2008 May. PMID 18391943, Free PMC Article
    2. Allatostatin-C/AstC-R2 Is a Novel Pathway to Modulate the Circadian Activity Pattern in Drosophila. Díaz MM, et al. Curr Biol, 2019 Jan 7. PMID 30554904, Free PMC Article
    3. Allatostatin C and its paralog allatostatin double C: the arthropod somatostatins. Veenstra JA. Insect Biochem Mol Biol, 2009 Mar. PMID 19063967
    4. Alleviation of thermal nociception depends on heat-sensitive neurons and a TRP channel in the brain. Liu J, et al. Curr Biol, 2023 Jun 19. PMID 37201520, Free PMC Article
    5. Functional annotation of two orphan G-protein-coupled receptors, Drostar1 and -2, from Drosophila melanogaster and their ligands by reverse pharmacology. Kreienkamp HJ, et al. J Biol Chem, 2002 Oct 18. PMID 12167655

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clock-neuron-derived AstC is required to mediate evening locomotor activity under short (winter-like) and long (summer-like) photoperiods. The AstC-Receptor 2 (AstC-R2) is expressed in dorsal-lateral neurons, the clock neurons that drive evening locomotor activity, and AstC-R2 is required in these neurons to modulate the same short photoperiod evening phenotype.
      Title: Allatostatin-C/AstC-R2 Is a Novel Pathway to Modulate the Circadian Activity Pattern in Drosophila.
    2. We expressed the Drosophila allatostatin receptor in somatostatin neurons in the preBotzinger Complex. Rapid silencing of these neurons in awake rats induced a persistent apnea without any respiratory movements to rescue their breathing.
      Title: Silencing preBötzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat.
    3. Drostar genes are required for visual information processing as well as endocrine regulation
      Title: Functional annotation of two orphan G-protein-coupled receptors, Drostar1 and -2, from Drosophila melanogaster and their ligands by reverse pharmacology.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables allatostatin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neuropeptide receptor activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables somatostatin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    allatostatin C receptor 2
    Names
    ASC-receptor
    AstC-R2-PB
    AstC-R2-PD
    AstC-R2-PE
    AstC-R2-PF
    CG13702-PB
    CG13702-PD
    CG13702-PE
    CG13702-PF
    allatostatin C receptor2
    drosophila allatostatin C receptor 2
    somatostatin receptor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18485137..18502557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001031964.2 → NP_001027135.2  allatostatin C receptor 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027135.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4ABJ7, Q8I943, Q8IQS9
      Conserved Domains (2) summary
      pfam00001
      Location:162 → 417
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:156 → 372
      7tm_4; Olfactory receptor

    2. NM_001316469.1 → NP_001303398.1  allatostatin C receptor 2, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S0WMT8, Q8I943
      Conserved Domains (2) summary
      pfam00001
      Location:162 → 417
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:156 → 372
      7tm_4; Olfactory receptor

    3. NM_001275086.1 → NP_001262015.1  allatostatin C receptor 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262015.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFL7, Q8I943
      Conserved Domains (2) summary
      pfam00001
      Location:162 → 417
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:156 → 372
      7tm_4; Olfactory receptor

    4. NM_140782.4 → NP_649039.4  allatostatin C receptor 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649039.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4ABJ7, Q8I943, Q8IQS9
      Related
      FBpp0088996, FBtr0089387
      Conserved Domains (2) summary
      pfam00001
      Location:162 → 417
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:156 → 372
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0S0WMT8 A0A0S0WMT8
    M9PFL7 M9PFL7
    Q8I943 Q8I943
    Q8IQS9 Q8IQS9
    Q8MTX9 Q8MTX9

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