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    sina seven in absentia [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39884, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sinaprovided by FlyBase
    Official Full Name
    seven in absentiaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003410
    Locus tag
    Dmel_CG9949
    See related
    AllianceGenome:FB:FBgn0003410
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe2H7; CG9949; Dmel\CG9949; sia; SIAH; Sina; SINA
    Summary
    Enables ubiquitin protein ligase activity. Involved in several processes, including positive regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of R7 cell differentiation; and sevenless signaling pathway. Located in cytosol and nucleus. Part of ubiquitin ligase complex. Is expressed in several structures, including embryonic/larval fat body; epithelium; gut section; imaginal disc; and sensory organ cell. Orthologous to several human genes including SIAH1 (siah E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sina in Genome Data Viewer
    Location:
    73D2-73D3; 3-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16853751..16858712)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16846851..16851812)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Tumor susceptibility gene 101 Neighboring gene kuduk Neighboring gene Zinc finger CCHC-type containing 7 Neighboring gene uncharacterized protein Neighboring gene Rhodopsin 4 Neighboring gene sina homologue Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene organization: nested genes take flight. Mount S, et al. Curr Biol, 1993 Jun 1. PMID 15335735
    2. Phylogenetic analysis of the SINA/SIAH ubiquitin E3 ligase family in Metazoa. Pepper IJ, et al. BMC Evol Biol, 2017 Aug 7. PMID 28784114, Free PMC Article
    3. Prepattern in the developing Drosophila eye revealed by an activated torso--sevenless chimeric receptor. Dickson B, et al. Genes Dev, 1992 Dec. PMID 1334023
    4. The presumptive R7 cell of the developing Drosophila eye receives positional information independent of sevenless, boss and sina. Mlodzik M, et al. Mech Dev, 1992 Mar. PMID 1606018
    5. A binding motif for Siah ubiquitin ligase. House CM, et al. Proc Natl Acad Sci U S A, 2003 Mar 18. PMID 12626763, Free PMC Article

    See all (157) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sina may be involved in regulating the levels of developmentally important transcription factors.
      Title: Two modes of degradation of the tramtrack transcription factors by Siah homologues.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in R7 cell fate commitment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in R7 cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in enteroendocrine cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasomal protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of R7 cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sevenless signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    seven in absentia
    Names
    CG9949-PA
    CG9949-PB
    CG9949-PC
    anon-fast-evolving-2H7
    seven in absenti
    seven-in-absentia
    sina-PA
    sina-PB
    sina-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16853751..16858712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057377.4 → NP_476725.1  seven in absentia, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476725.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V214, P21461, Q9VVB0
      UniProtKB/TrEMBL
      X2JB60
      Related
      FBpp0075091
      Conserved Domains (3) summary
      cd00162
      Location:73 → 107
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam03145
      Location:114 → 310
      Sina; Seven in absentia protein family
      cl17238
      Location:71 → 110
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. NM_001300160.1 → NP_001287089.1  seven in absentia, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287089.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V214, P21461, Q9VVB0
      UniProtKB/TrEMBL
      X2JB60
      Conserved Domains (3) summary
      cd00162
      Location:73 → 107
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam03145
      Location:114 → 310
      Sina; Seven in absentia protein family
      cl17238
      Location:71 → 110
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. NM_168689.2 → NP_730206.1  seven in absentia, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730206.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V214, P21461, Q9VVB0
      UniProtKB/TrEMBL
      X2JB60
      Related
      FBpp0075092
      Conserved Domains (3) summary
      cd00162
      Location:73 → 107
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam03145
      Location:114 → 310
      Sina; Seven in absentia protein family
      cl17238
      Location:71 → 110
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21461.2 P21461
    X2JB60 X2JB60

    Gene LinkOut

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