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    INPP5E Inositol polyphosphate 5-phosphatase E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39404, updated on 9-Dec-2024

    Summary

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    Official Symbol
    INPP5Eprovided by FlyBase
    Official Full Name
    Inositol polyphosphate 5-phosphatase Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036273
    Locus tag
    Dmel_CG10426
    See related
    AllianceGenome:FB:FBgn0036273
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10426; dInpp5e; Dmel\CG10426; Inpp5e; INPPE5; IPP
    Summary
    Predicted to enable phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in protein localization to cilium and sensory perception of sound. Located in ciliary base. Is expressed in several structures, including eye disc; gland; larval central nervous system; larval peripheral nervous system; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in Joubert syndrome and Joubert syndrome 1. Orthologous to human INPP5E (inositol polyphosphate-5-phosphatase E). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See INPP5E in Genome Data Viewer
    Location:
    69A5-69A5; 3-38 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12277655..12281476)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12270755..12274576)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Porphobilinogen synthase Neighboring gene Spermine synthase Neighboring gene long non-coding RNA:CR46241 Neighboring gene long non-coding RNA:CR45658

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ciliary Phosphoinositide Regulates Ciliary Protein Trafficking in Drosophila. Park J, et al. Cell Rep, 2015 Dec 29. PMID 26723017
    2. A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster. Seeds AM, et al. J Biol Chem, 2004 Nov 5. PMID 15322119
    3. Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells. Zirin J, et al. Proc Natl Acad Sci U S A, 2019 Jul 16. PMID 31262815, Free PMC Article
    4. Phosphoinositides and Cell Polarity in the Drosophila Egg Chamber. Jouette J, et al. Results Probl Cell Differ, 2017. PMID 28779318
    5. Hypoxia controls plasma membrane targeting of polarity proteins by dynamic turnover of PI4P and PI(4,5)P2. Lu J, et al. Elife, 2022 Jun 9. PMID 35678383, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to cilium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sound IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in ciliary base IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary base IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    inositol polyphosphate 5-phosphatase E
    Names
    CG10426-PA
    CG10426-PB
    INPP5E-PA
    INPP5E-PB
    pharbin-like
    NP_001261753.1
    NP_648566.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12277655..12281476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140309.2 → NP_648566.1  inositol polyphosphate 5-phosphatase E, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648566.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VTW2
      Related
      FBpp0075739
      Conserved Domains (1) summary
      cl00490
      Location:387 → 703
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    2. NM_001274824.1 → NP_001261753.1  inositol polyphosphate 5-phosphatase E, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261753.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VTW2
      Conserved Domains (1) summary
      cl00490
      Location:387 → 703
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTW2.1 Q9VTW2

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