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    Fit1 Fermitin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38488, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Fit1provided by FlyBase
    Official Full Name
    Fermitin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035498
    Locus tag
    Dmel_CG14991
    See related
    AllianceGenome:FB:FBgn0035498
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.421; CG14991; Dmel\CG14991; fit 1; Fit 1; fit1
    Summary
    Predicted to enable integrin binding activity. Involved in cardiac muscle tissue development and defense response to Gram-negative bacterium. Predicted to be located in cytoplasm. Predicted to be active in cell-substrate junction. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in Kindler syndrome; leukocyte adhesion deficiency 1; leukocyte adhesion deficiency 3; telangiectasis; and vesiculobullous skin disease. Orthologous to several human genes including FERMT1 (FERM domain containing kindlin 1) and FERMT2 (FERM domain containing kindlin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fit1 in Genome Data Viewer
    Location:
    64A6-64A6; 3-10 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4103564..4107116)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4103564..4107116)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Glutamic acid decarboxylase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45670 Neighboring gene Activated Cdc42 kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FERMT2 links cortical actin structures, plasma membrane tension and focal adhesion function to stabilize podocyte morphology. Yasuda-Yamahara M, et al. Matrix Biol, 2018 Aug. PMID 29337051
    2. Fermitins, the orthologs of mammalian Kindlins, regulate the development of a functional cardiac syncytium in Drosophila melanogaster. Catterson JH, et al. PLoS One, 2013. PMID 23690969, Free PMC Article
    3. Drosophila integrin adhesion complexes are essential for hemocyte migration in vivo. Moreira CG, et al. Biol Open, 2013 Aug 15. PMID 23951405, Free PMC Article
    4. Actin-driven nanotopography promotes stable integrin adhesion formation in developing tissue. Chen T, et al. Nat Commun, 2024 Oct 7. PMID 39375335, Free PMC Article
    5. Drosophila vinculin is more harmful when hyperactive than absent, and can circumvent integrin to form adhesion complexes. Maartens AP, et al. J Cell Sci, 2016 Dec 1. PMID 27737911, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cell adhesion molecule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiac muscle tissue development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell-substrate junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    fermitin 1
    Names
    CG14991-PA
    CG14991-PB
    Fermitin1
    Fit1-PA
    Fit1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4103564..4107116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139601.4 → NP_647858.2  fermitin 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647858.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1G3, Q95SD2, Q9VZI3
      Related
      FBpp0073066
      Conserved Domains (5) summary
      cd01237
      Location:401 → 529
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      cd13205
      Location:596 → 686
      FERM_C_fermitin; FERM domain C-lobe of the Fermitin family
      pfam00169
      Location:401 → 508
      PH; PH domain
      pfam00373
      Location:538 → 602
      FERM_M; FERM central domain
      cl09511
      Location:305 → 348
      FERM_B-lobe; FERM domain B-lobe

    2. NM_168060.3 → NP_728936.1  fermitin 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728936.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1G3, Q95SD2, Q9VZI3
      Related
      FBpp0073065
      Conserved Domains (5) summary
      cd01237
      Location:401 → 529
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      cd13205
      Location:596 → 686
      FERM_C_fermitin; FERM domain C-lobe of the Fermitin family
      pfam00169
      Location:401 → 508
      PH; PH domain
      pfam00373
      Location:538 → 602
      FERM_M; FERM central domain
      cl09511
      Location:305 → 348
      FERM_B-lobe; FERM domain B-lobe
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZI3.1 Q9VZI3

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