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    Eip63E Ecdysone-induced protein 63E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38433, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eip63Eprovided by FlyBase
    Official Full Name
    Ecdysone-induced protein 63Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0005640
    Locus tag
    Dmel_CG10579
    See related
    AllianceGenome:FB:FBgn0005640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cdc2-63E; CG10579; Dmel\CG10579; EIP63E; L63; Pftaire; PFTAIRE
    Summary
    Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including embryonic development via the syncytial blastoderm; instar larval development; and positive regulation of canonical Wnt signaling pathway. Located in cytosol and plasma membrane. Is expressed in several structures, including adult brain; adult brain cell body rind; embryonic/larval midgut primordium; glial cell; and somatic precursor cell. Orthologous to several human genes including CDK14 (cyclin dependent kinase 14). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Eip63E in Genome Data Viewer
    Location:
    63E3-63E5; 3-8 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3515751..3610521)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3515751..3610521)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45043 Neighboring gene Ecdysone-inducible gene E2 Neighboring gene long non-coding RNA:CR45820 Neighboring gene small nuclear RNA U7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. U7 snRNA mutations in Drosophila block histone pre-mRNA processing and disrupt oogenesis. Godfrey AC, et al. RNA, 2006 Mar. PMID 16495235, Free PMC Article
    2. PFTK1 kinase regulates axogenesis during development via RhoA activation. González YR, et al. BMC Biol, 2023 Oct 31. PMID 37907898, Free PMC Article
    3. The L63 gene is necessary for the ecdysone-induced 63E late puff and encodes CDK proteins required for Drosophila development. Stowers RS, et al. Dev Biol, 2000 May 1. PMID 10772789
    4. Cyclin Y is a novel conserved cyclin essential for development in Drosophila. Liu D, et al. Genetics, 2010 Apr. PMID 20100936, Free PMC Article
    5. L63, the Drosophila PFTAIRE, interacts with two novel proteins unrelated to cyclins. Rascle A, et al. Mech Dev, 2003 May. PMID 12782278

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PFTK1 kinase regulates axogenesis during development via RhoA activation.
      Title: PFTK1 kinase regulates axogenesis during development via RhoA activation.
    2. L63 is the Drosophila PFTAIRE and interacts with two novel proteins unrelated to cyclins
      Title: L63, the Drosophila PFTAIRE, interacts with two novel proteins unrelated to cyclins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 3601354-3606606 mobile_element_type = transposon:copia{}920

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic development via the syncytial blastoderm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in instar larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metamorphosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    Ecdysone-induced protein 63E
    Names
    CG10579-PA
    CG10579-PB
    CG10579-PC
    CG10579-PD
    CG10579-PE
    CG10579-PF
    CG10579-PG
    CG10579-PH
    CG10579-PI
    CG10579-PJ
    CG10579-PK
    CG10579-PL
    CG10579-PM
    CG10579-PN
    Eip63E-PA
    Eip63E-PB
    Eip63E-PC
    Eip63E-PD
    Eip63E-PE
    Eip63E-PF
    Eip63E-PG
    Eip63E-PH
    Eip63E-PI
    Eip63E-PJ
    Eip63E-PK
    Eip63E-PL
    Eip63E-PM
    Eip63E-PN
    PFTAIRE
    NP_001036581.1
    NP_001036582.1
    NP_001036583.1
    NP_001036584.1
    NP_001036585.1
    NP_001036586.1
    NP_001163340.1
    NP_001189042.1
    NP_001261373.1
    NP_523904.1
    NP_728888.1
    NP_728889.1
    NP_728890.1
    NP_728891.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3515751..3610521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202113.2 → NP_001189042.1  Ecdysone-induced protein 63E, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189042.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VUZ5, Q7KM08
      Conserved Domains (2) summary
      PLN00009
      Location:190 → 479
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07844
      Location:191 → 476
      STKc_PCTAIRE_like; Catalytic domain of PCTAIRE-like Serine/Threonine Kinases

    2. NM_079180.4 → NP_523904.1  Ecdysone-induced protein 63E, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523904.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QP46, Q8IRC9, Q9U9S9, Q9U9T0, Q9XTK9, Q9XTM5, Q9Y0H8
      Related
      FBpp0072990
      Conserved Domains (2) summary
      PLN00009
      Location:203 → 492
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07844
      Location:204 → 489
      STKc_PCTAIRE_like; Catalytic domain of PCTAIRE-like Serine/Threonine Kinases

    3. NM_001274444.1 → NP_001261373.1  Ecdysone-induced protein 63E, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261373.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QP46, M9PE01
      Conserved Domains (2) summary
      PLN00009
      Location:203 → 492
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07844
      Location:204 → 489
      STKc_PCTAIRE_like; Catalytic domain of PCTAIRE-like Serine/Threonine Kinases

    4. NM_001043116.3 → NP_001036581.1  Ecdysone-induced protein 63E, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036581.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VUZ5, Q7KM08
      Conserved Domains (2) summary
      PLN00009
      Location:190 → 479
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07844
      Location:191 → 476
      STKc_PCTAIRE_like; Catalytic domain of PCTAIRE-like Serine/Threonine Kinases

    5. NM_168033.3 → NP_728888.1  Ecdysone-induced protein 63E, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728888.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QP46, Q8IRC9, Q9U9S9, Q9U9T0, Q9XTK9, Q9XTM5, Q9Y0H8
      Related
      FBpp0072991
      Conserved Domains (2) summary
      PLN00009
      Location:203 → 492
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07844
      Location:204 → 489
      STKc_PCTAIRE_like; Catalytic domain of PCTAIRE-like Serine/Threonine Kinases

    6. NM_001043119.3 → NP_001036584.1  Ecdysone-induced protein 63E, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036584.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QP46, Q7KM03
      Conserved Domains (1) summary
      cd07844
      Location:204 → 489
      STKc_PCTAIRE_like; Catalytic domain of PCTAIRE-like Serine/Threonine Kinases

    7. NM_168034.3 → NP_728889.1  Ecdysone-induced protein 63E, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728889.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VUZ5, Q7KM05
      Related
      FBpp0072992
      Conserved Domains (1) summary
      cd07844
      Location:191 → 476
      STKc_PCTAIRE_like; Catalytic domain of PCTAIRE-like Serine/Threonine Kinases

    8. NM_001043120.3 → NP_001036585.1  Ecdysone-induced protein 63E, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036585.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QP46, Q7KM03
      Conserved Domains (1) summary
      cd07844
      Location:204 → 489
      STKc_PCTAIRE_like; Catalytic domain of PCTAIRE-like Serine/Threonine Kinases

    9. NM_168035.2 → NP_728890.1  Ecdysone-induced protein 63E, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728890.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VUZ5, Q7KM05
      Related
      FBpp0072993
      Conserved Domains (1) summary
      cd07844
      Location:191 → 476
      STKc_PCTAIRE_like; Catalytic domain of PCTAIRE-like Serine/Threonine Kinases

    10. NM_001043117.3 → NP_001036582.1  Ecdysone-induced protein 63E, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036582.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QP46, Q7KM04
      Conserved Domains (1) summary
      cd07844
      Location:183 → 468
      STKc_PCTAIRE_like; Catalytic domain of PCTAIRE-like Serine/Threonine Kinases

    11. NM_001169869.2 → NP_001163340.1  Ecdysone-induced protein 63E, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163340.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QP46, Q7KM03
      Conserved Domains (1) summary
      cd07844
      Location:204 → 489
      STKc_PCTAIRE_like; Catalytic domain of PCTAIRE-like Serine/Threonine Kinases

    12. NM_001043118.3 → NP_001036583.1  Ecdysone-induced protein 63E, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036583.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QP46, Q7KM03
      Conserved Domains (1) summary
      cd07844
      Location:204 → 489
      STKc_PCTAIRE_like; Catalytic domain of PCTAIRE-like Serine/Threonine Kinases

    13. NM_168036.3 → NP_728891.1  Ecdysone-induced protein 63E, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728891.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VUZ5, Q7KM05
      Related
      FBpp0072994
      Conserved Domains (1) summary
      cd07844
      Location:191 → 476
      STKc_PCTAIRE_like; Catalytic domain of PCTAIRE-like Serine/Threonine Kinases

    14. NM_001043121.2 → NP_001036586.1  Ecdysone-induced protein 63E, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036586.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VUZ5, Q7KM05
      Conserved Domains (1) summary
      cd07844
      Location:191 → 476
      STKc_PCTAIRE_like; Catalytic domain of PCTAIRE-like Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PE01 M9PE01
    Q7KM03 Q7KM03
    Q7KM04 Q7KM04
    Q7KM05 Q7KM05
    Q7KM08 Q7KM08
    Q7YUC0 Q7YUC0
    Q8MZ44 Q8MZ44
    Q94888 Q94888
    Q9XTK9 Q9XTK9

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