Atg2 Autophagy-related 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Atg2provided by FlyBase
Official Full Name: Autophagy-related 2provided by FlyBase
Primary source: FLYBASE:FBgn0044452
Locus tag: Dmel_CG1241
See related: AllianceGenome:FB:FBgn0044452
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: atg2; ATG2; CG1241; Dmel\CG1241; EP3697
Summary: Predicted to enable phosphatidylinositol-3-phosphate binding activity and protein-membrane adaptor activity. Involved in cellular response to starvation; larval midgut cell programmed cell death; and macroautophagy. Predicted to be active in phagophore and phagophore assembly site. Is expressed in adult head and salivary gland. Orthologous to human ATG2A (autophagy related 2A) and ATG2B (autophagy related 2B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 62F3-62F4; 3-4 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (2774338..2780677)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (2774338..2780677)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Muscle-specific overexpression of Atg2 gene and endurance exercise delay age-related deteriorations of skeletal muscle and heart function via activating the AMPK/Sirt1/PGC-1alpha pathway in male Drosophila.
Title: Muscle-specific overexpression of Atg2 gene and endurance exercise delay age-related deteriorations of skeletal muscle and heart function via activating the AMPK/Sirt1/PGC-1α pathway in male Drosophila.
Lipid profiles of autophagic structures isolated from wild type and Atg2 mutant Drosophila.
Title: Lipid profiles of autophagic structures isolated from wild type and Atg2 mutant Drosophila.
These findings provide the first direct evidence of the importance of Atg2-Atg18/Atg9 autophagy complex in the maintenance of mitochondrial integrity and, regulation of heart and muscle functions in Drosophila.
Title: Atg2, Atg9 and Atg18 in mitochondrial integrity, cardiac function and healthspan in Drosophila.
Stusy results reveal Atg2 regulation by STAT signalling as a mechanism by which cytokines can control lipid droplet homeostasis and consequently resistance to mycobacterial infection in Drosophila.
Title: Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection.
double knockdown of tlk and atg2 by RNAi did not have a synergistic effect. These results suggested that ATG2 may function downstream of TLK. In addition to a role in development, tlk and atg2 RNAi could rescue calcium overload-induced cell death
Title: Tousled-like kinase mediated a new type of cell death pathway in Drosophila.
Atg2 and ArfGAP1 may have roles in modifying the eye pigmentation phenotype of AP-3 mutants in Drosophila melanogaster
Title: Identification of Atg2 and ArfGAP1 as Candidate Genetic Modifiers of the Eye Pigmentation Phenotype of Adaptor Protein-3 (AP-3) Mutants in Drosophila melanogaster.
The transmembrane protein Atg9 accumulates on refractory to Sigma P (Ref(2)P) aggregates in Atg7, Atg8a and Atg2 mutants.
Title: Different effects of Atg2 and Atg18 mutations on Atg8a and Atg9 trafficking during starvation in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1560 (e-PCR)
- UniSTS:49090

Dm1561 (e-PCR)
- UniSTS:17905

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables phosphatidylinositol-3-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-membrane adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval midgut cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval midgut histolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pexophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in wound healing	HMP more info	PubMed

Component	Evidence Code	Pubs
is_active_in phagophore	IBA Inferred from Biological aspect of Ancestor more info
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Autophagy-related 2

Names: Atg2-PA; Atg2-PB; Autophagy-specific gene 2; CG1241-PA; CG1241-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

2774338..2780677

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274412.1 → NP_001261341.1 Autophagy-related 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261341.1

Status: REVIEWED

UniProtKB/TrEMBL

Q2XXT6, Q9VZX7

Conserved Domains (2) summary

pfam09333
Location:1814 → 1902

ATG_C; Autophagy-related protein C terminal domain

pfam12624
Location:17 → 117

Chorein_N; N-terminal region of Chorein or VPS13
NM_139491.2 → NP_647748.1 Autophagy-related 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_647748.1

Status: REVIEWED

UniProtKB/TrEMBL

Q2XXT6, Q9VZX7

Related

FBpp0072840

Conserved Domains (2) summary

pfam09333
Location:1814 → 1902

ATG_C; Autophagy-related protein C terminal domain

pfam12624
Location:17 → 117

Chorein_N; N-terminal region of Chorein or VPS13