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    Pcyt1 Phosphocholine cytidylyltransferase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 117353, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pcyt1provided by FlyBase
    Official Full Name
    Phosphocholine cytidylyltransferase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0041342
    Locus tag
    Dmel_CG1049
    See related
    AllianceGenome:FB:FBgn0041342
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Cct; cct1; Cct1; CCT1; CG1049; CT41283; Dmel\CG1049; pcyt1
    Summary
    Enables choline-phosphate cytidylyltransferase activity. Involved in several processes, including determination of adult lifespan; establishment of ommatidial planar polarity; and imaginal disc-derived wing morphogenesis. Located in nucleus. Is expressed in several structures, including adult head; amnioserosa primordium; anterior endoderm; embryonic/larval midgut primordium; and epithelium. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy and spondylometaphyseal dysplasia with cone-rod dystrophy. Orthologous to human PCYT1A (phosphate cytidylyltransferase 1A, choline). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pcyt1 in Genome Data Viewer
    Location:
    62A3-62A5; 3-0.5 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1546092..1553504)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1546092..1553504)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pinstripe Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45813 Neighboring gene Phosphocholine cytidylyltransferase 2 Neighboring gene uncharacterized protein Neighboring gene Peroxin 10 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of the nuclear isoform of Drosophila melanogaster CTP:phosphocholine cytidylyltransferase. Tilley DM, et al. Biochemistry, 2008 Nov 11. PMID 18922025
    2. Characterization of a lipid activated CTP:phosphocholine cytidylyltransferase from Drosophila melanogaster. Helmink BA, et al. Biochim Biophys Acta, 2004 Jul 5. PMID 15238222
    3. Membrane Asymmetry Imposes Directionality on Lipid Droplet Emergence from the ER. Chorlay A, et al. Dev Cell, 2019 Jul 1. PMID 31155466
    4. Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase. Krahmer N, et al. Cell Metab, 2011 Oct 5. PMID 21982710, Free PMC Article
    5. Torsins Are Essential Regulators of Cellular Lipid Metabolism. Grillet M, et al. Dev Cell, 2016 Aug 8. PMID 27453503

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CTP:phosphocholine cytidylyltransferase regulates phospholipid homeostatis druing lipid droplets expansion.
      Title: Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase.
    2. Proteomic analysis reveals Cct1 is a target of FMR1 protein regulation in Drosophila.
      Title: Proteomic analysis reveals CCT is a target of Fragile X mental retardation protein regulation in Drosophila.
    3. CCT1 was identified as the nuclear isoform.
      Title: Identification and characterization of the nuclear isoform of Drosophila melanogaster CTP:phosphocholine cytidylyltransferase.
    4. Data provide evidence for a specific role for CTP: phosphocholine cytidylyltransferase, and thus for phosphatidylcholine, in patterning during development.
      Title: Cct1, a phosphatidylcholine biosynthesis enzyme, is required for Drosophila oogenesis and ovarian morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables choline-phosphate cytidylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables choline-phosphate cytidylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables choline-phosphate cytidylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-choline pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of ommatidial planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylcholine biosynthetic process IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphocholine cytidylyltransferase 1
    Names
    CG1049-PA
    CG1049-PB
    CG1049-PC
    CG1049-PD
    CG1049-PE
    CG1049-PF
    CTP-phosphocholine cytidylyltransferase
    CTP:phosphocholine cytidylyltransferase
    CTP:phosphocholine cytidylyltransferase 1
    Pcyt1-PA
    Pcyt1-PB
    Pcyt1-PC
    Pcyt1-PD
    Pcyt1-PE
    Pcyt1-PF
    cytidylyltransferase 1
    phosphocholine cytidylyltransferase
    NP_001261264.1
    NP_001286898.1
    NP_647621.1
    NP_728626.1
    NP_728627.1
    NP_728628.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1546092..1553504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299969.1 → NP_001286898.1  phosphocholine cytidylyltransferase 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286898.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K4C7
      Conserved Domains (2) summary
      cd02174
      Location:204 → 353
      CCT; CTP:phosphocholine cytidylyltransferase
      PLN02413
      Location:202 → 462
      PLN02413; choline-phosphate cytidylyltransferase

    2. NM_001274335.1 → NP_001261264.1  phosphocholine cytidylyltransferase 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261264.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K4C7
      Conserved Domains (2) summary
      cd02174
      Location:204 → 353
      CCT; CTP:phosphocholine cytidylyltransferase
      PLN02413
      Location:202 → 462
      PLN02413; choline-phosphate cytidylyltransferase

    3. NM_139364.3 → NP_647621.1  phosphocholine cytidylyltransferase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647621.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K4C7
      Related
      FBpp0072621
      Conserved Domains (2) summary
      cd02174
      Location:204 → 353
      CCT; CTP:phosphocholine cytidylyltransferase
      PLN02413
      Location:202 → 462
      PLN02413; choline-phosphate cytidylyltransferase

    4. NM_167894.2 → NP_728628.1  phosphocholine cytidylyltransferase 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728628.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K4C7
      Related
      FBpp0072622
      Conserved Domains (2) summary
      cd02174
      Location:204 → 353
      CCT; CTP:phosphocholine cytidylyltransferase
      PLN02413
      Location:202 → 462
      PLN02413; choline-phosphate cytidylyltransferase

    5. NM_167892.2 → NP_728626.1  phosphocholine cytidylyltransferase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728626.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K4C7
      Related
      FBpp0072623
      Conserved Domains (2) summary
      cd02174
      Location:204 → 353
      CCT; CTP:phosphocholine cytidylyltransferase
      PLN02413
      Location:202 → 462
      PLN02413; choline-phosphate cytidylyltransferase

    6. NM_167893.2 → NP_728627.1  phosphocholine cytidylyltransferase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728627.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K4C7
      Related
      FBpp0072624
      Conserved Domains (2) summary
      cd02174
      Location:204 → 353
      CCT; CTP:phosphocholine cytidylyltransferase
      PLN02413
      Location:202 → 462
      PLN02413; choline-phosphate cytidylyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K4C7 Q7K4C7

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