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    Vdup1 Vitamin D[[3]] up-regulated protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38023, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vdup1provided by FlyBase
    Official Full Name
    Vitamin D[[3]] up-regulated protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035103
    Locus tag
    Dmel_CG7047
    See related
    AllianceGenome:FB:FBgn0035103
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7047; Dmel\CG7047; dvdup1; TXNIP; vdup1; VDUP1
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Involved in cell redox homeostasis and negative regulation of removal of superoxide radicals. Located in cytoplasm and nucleus. Is expressed in several structures, including adult fat body; epidermis; germline cell; glial cell; and gut section. Orthologous to human ARRDC1 (arrestin domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vdup1 in Genome Data Viewer
    Location:
    61B2-61B2; 3-1 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (176306..178963, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (176306..178963, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene p130CAS Neighboring gene long non-coding RNA:CR43151 Neighboring gene antisense RNA:CR45806 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene MAP kinase-specific phosphatase Neighboring gene Mitochondrial carrier homolog 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hedgehog-dependent down-regulation of the tumor suppressor, vitamin D3 up-regulated protein 1 (VDUP1), precedes lamina development in Drosophila. Chang S, et al. Brain Res, 2010 Apr 9. PMID 20138028
    2. Expression and regulation of vitamin D3 upregulated protein 1 (VDUP1) is conserved in mammalian and insect brain. Levendusky MC, et al. J Comp Neurol, 2009 Dec 10. PMID 19824090
    3. Evolutionarily Conserved Role of Thioredoxin Systems in Determining Longevity. AlOkda A, et al. Antioxidants (Basel), 2023 Apr 17. PMID 37107319, Free PMC Article
    4. The tumor suppressor, vitamin D3 up-regulated protein 1 (VDUP1), functions downstream of REPO during Drosophila gliogenesis. Mandalaywala NV, et al. Dev Biol, 2008 Mar 15. PMID 18262515
    5. Enhanced expression of thioredoxin-interacting-protein regulates oxidative DNA damage and aging. Oberacker T, et al. FEBS Lett, 2018 Jul. PMID 29897613, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Age-dependent upregulation of TXNIP results in decreased stress resistance to oxidative challenge in primary human cells and in Drosophila. Experimental overexpression of TXNIP in flies shortens lifespan due to elevated oxidative DNA damage, whereas downregulation of TXNIP enhances oxidative stress resistance and extends lifespan.
      Title: Enhanced expression of thioredoxin-interacting-protein regulates oxidative DNA damage and aging.
    2. Hh regulates VDUP1 in the developing lamina; Hh loss-of-function inhibits cell proliferation and lamina neurogenesis. The coupling of VDUP1 to the Hh signaling pathway may provide novel insights into the mechanisms controlling brain growth and development
      Title: Hedgehog-dependent down-regulation of the tumor suppressor, vitamin D3 up-regulated protein 1 (VDUP1), precedes lamina development in Drosophila.
    3. Study shows evolutionarily conserved expression patterns of VDUP1 in Drosophila and rat nervous systems, including subcellular localization--cytoplasmic enrichment in neurons and nuclear expression in glia.
      Title: Expression and regulation of vitamin D3 upregulated protein 1 (VDUP1) is conserved in mammalian and insect brain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of removal of superoxide radicals IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vitamin D[[3]] up-regulated protein 1
    Names
    CG7047-PA
    CG7047-PB
    CG7047-PC
    CG7047-PD
    CG7047-PE
    Vdup1-PA
    Vdup1-PB
    Vdup1-PC
    Vdup1-PD
    Vdup1-PE
    vitamin D3 up-regulated protein 1
    vitamin-D[[3]] upregulated protein 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      176306..178963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169832.2 → NP_001163303.1  vitamin D[[3]] up-regulated protein 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163303.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8K8, Q8SYE1
      Conserved Domains (2) summary
      smart01017
      Location:171 → 299
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:8 → 145
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    2. NM_001274255.1 → NP_001261184.1  vitamin D[[3]] up-regulated protein 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261184.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8K8, Q8SYE1
      Conserved Domains (2) summary
      smart01017
      Location:171 → 299
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:8 → 145
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    3. NM_138160.4 → NP_612004.2  vitamin D[[3]] up-regulated protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612004.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8K8, Q8SYE1
      Related
      FBpp0072433
      Conserved Domains (2) summary
      smart01017
      Location:171 → 299
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:8 → 145
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    4. NM_167798.3 → NP_728479.1  vitamin D[[3]] up-regulated protein 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728479.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8K8, Q8SYE1
      Related
      FBpp0072434
      Conserved Domains (2) summary
      smart01017
      Location:171 → 299
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:8 → 145
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    5. NM_206221.3 → NP_995943.1  vitamin D[[3]] up-regulated protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995943.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8K8, Q8SYE1
      Conserved Domains (2) summary
      smart01017
      Location:171 → 299
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:8 → 145
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E8K8 Q0E8K8
    Q8SYE1 Q8SYE1
    Q8SYW4 Q8SYW4

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