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    CG42748 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35442, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG42748provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261802
    Locus tag
    Dmel_CG42748
    See related
    AllianceGenome:FB:FBgn0261802
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.28; CG15216; CG15217; CG6448; Dmel\CG42748
    Old locus tag
    Dmel_CG15216; Dmel_CG6448
    Summary
    Enables protein phosphatase 1 binding activity. Predicted to be involved in cell-cell junction organization. Located in lateral plasma membrane. Is expressed in several structures, including adult head; central brain primordium; embryonic central brain neurons; epidermis; and ganglia. Orthologous to human AJM1 (apical junction component 1 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG42748 in Genome Data Viewer
    Location:
    40E5-40F2; 2-54 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (22131221..22166221)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22131221..22166221)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43241 Neighboring gene Cyclin K Neighboring gene pseudo Neighboring gene disrupted underground network Neighboring gene long non-coding RNA:CR44809 Neighboring gene Chromatin-linked adaptor for MSL proteins Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Apical constriction drives tissue-scale hydrodynamic flow to mediate cell elongation. He B, et al. Nature, 2014 Apr 17. PMID 24590071, Free PMC Article
    2. Towards a comprehensive analysis of the protein phosphatase 1 interactome in Drosophila. Bennett D, et al. J Mol Biol, 2006 Nov 24. PMID 17007873
    3. Estimation of isolation times of the island species in the Drosophila simulans complex from multilocus DNA sequence data. McDermott SR, et al. PLoS One, 2008 Jun 18. PMID 18560591, Free PMC Article
    4. Post-transcriptional repression of the Drosophila midkine and pleiotrophin homolog miple by HOW is essential for correct mesoderm spreading. Toledano-Katchalski H, et al. Development, 2007 Oct. PMID 17728343
    5. SCORE: a computational approach to the identification of cis-regulatory modules and target genes in whole-genome sequence data. Site clustering over random expectation. Rebeiz M, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12107285, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 22133546-22133845 mobile_element_type = transposon:S{}532
    • Loc: 22135450-22136081 mobile_element_type = transposon:Tc3{}2279
    • Loc: 22145280-22145514 mobile_element_type = transposon:INE-1{}6125
    • Loc: 22154099-22156468 mobile_element_type = transposon:INE-1{}6126
    • Loc: 22159423-22159478 mobile_element_type = transposon:INE-1{}6127
    • Loc: 22159968-22160009 mobile_element_type = transposon:INE-1{}6128
    • Loc: 22163258-22163806 mobile_element_type = transposon:INE-1{}6134

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein phosphatase 1 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lateral plasma membrane HDA PubMed 
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42748-PB
    CG42748-PC
    CG42748-PD
    CG42748-PE
    CG42748-PF
    CG42748-PG
    CG42748-PH
    CG42748-PJ
    CG42748-PK
    CG42748-PL
    CG42748-PM

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      22131221..22166221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273754.1 → NP_001260683.1  uncharacterized protein Dmel_CG42748, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260683.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBG0
      Conserved Domains (1) summary
      COG5422
      Location:1504 → 1678
      ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]

    2. NM_001103720.3 → NP_001097190.2  uncharacterized protein Dmel_CG42748, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097190.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      R9PY70
      Conserved Domains (1) summary
      pfam01753
      Location:1819 → 1850
      zf-MYND; MYND finger

    3. NM_001273755.1 → NP_001260684.1  uncharacterized protein Dmel_CG42748, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260684.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDE6
      Conserved Domains (1) summary
      pfam01753
      Location:1870 → 1901
      zf-MYND; MYND finger

    4. NM_001273757.1 → NP_001260686.1  uncharacterized protein Dmel_CG42748, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260686.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDL8

    5. NM_165411.3 → NP_724384.1  uncharacterized protein Dmel_CG42748, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724384.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9N7
      Related
      FBpp0292363

    6. NM_001103718.3 → NP_001097188.1  uncharacterized protein Dmel_CG42748, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097188.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DZ24

    7. NM_136290.4 → NP_610134.2  uncharacterized protein Dmel_CG42748, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610134.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9N7
      Related
      FBpp0292364
      Conserved Domains (1) summary
      PRK08853
      Location:955 → 1106
      PRK08853; DNA polymerase III subunits gamma and tau; Validated

    8. NM_001273756.1 → NP_001260685.1  uncharacterized protein Dmel_CG42748, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260685.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDY6
      Conserved Domains (2) summary
      pfam01753
      Location:502 → 533
      zf-MYND; MYND finger
      pfam16642
      Location:278 → 352
      KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

    9. NM_001201933.1 → NP_001188862.1  uncharacterized protein Dmel_CG42748, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188862.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A2VEE9, M9MSJ5

    10. NM_136292.2 → NP_610136.2  uncharacterized protein Dmel_CG42748, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610136.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9N5
      Conserved Domains (1) summary
      pfam01753
      Location:458 → 489
      zf-MYND; MYND finger

    11. NM_001103719.4 → NP_001097189.2  uncharacterized protein Dmel_CG42748, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097189.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DZ25
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DZ24 A8DZ24
    A8DZ25 A8DZ25
    M9MSJ5 M9MSJ5
    M9PBG0 M9PBG0
    M9PDE6 M9PDE6
    M9PDL8 M9PDL8
    M9PDY6 M9PDY6
    Q9V9N5 Q9V9N5
    Q9V9N7 Q9V9N7
    R9PY70 R9PY70

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