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    nesd nessun dorma [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35298, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nesdprovided by FlyBase
    Official Full Name
    nessun dormaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032848
    Locus tag
    Dmel_CG10722
    See related
    AllianceGenome:FB:FBgn0032848
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    38B.16; CG10722; Dmel\CG10722
    Summary
    Enables carbohydrate binding activity. Involved in female germline ring canal stabilization and male meiosis cytokinesis. Located in several cellular components, including fusome; male germline ring canal; and midbody. Part of centralspindlin complex. Is expressed in organism and testis. Orthologous to several human genes including SHCBP1 (SHC binding and spindle associated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nesd in Genome Data Viewer
    Location:
    38B6-38B6; 2-54 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20093972..20096253)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20093972..20096253)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene nebbish Neighboring gene uncharacterized protein Neighboring gene Pyridine nucleotide-disulfide oxidoreductase domain 1 Neighboring gene TBP-associated factor 13 Neighboring gene mitochondrial ribosomal protein S18B Neighboring gene Kua

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ectopic assembly of heterochromatin in Drosophila melanogaster triggered by transposable elements. Sentmanat MF, et al. Proc Natl Acad Sci U S A, 2012 Aug 28. PMID 22891327, Free PMC Article
    2. Nessun Dorma, a novel centralspindlin partner, is required for cytokinesis in Drosophila spermatocytes. Montembault E, et al. J Cell Biol, 2010 Dec 27. PMID 21187330, Free PMC Article
    3. Using qualitative probability in reverse-engineering gene regulatory networks. Ibrahim ZM, et al. IEEE/ACM Trans Comput Biol Bioinform, 2011 Mar-Apr. PMID 20876933
    4. What Drosophila spermatocytes tell us about the mechanisms underlying cytokinesis. Giansanti MG, et al. Cytoskeleton (Hoboken), 2012 Nov. PMID 22927345, Free PMC Article
    5. DAPPER: a data-mining resource for protein-protein interactions. Haider S, et al. BioData Min, 2015. PMID 26405458, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in female germline ring canal stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male meiosis cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male meiosis cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of centralspindlin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in female germline ring canal IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fusome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in male germline ring canal IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nessun dorma
    Names
    CG10722-PA
    CG10722-PB
    nesd-PA
    nesd-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      20093972..20096253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136181.2 → NP_610025.1  nessun dorma, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610025.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NP13, Q9VIP0
      Related
      FBpp0080867

    2. NM_165320.2 → NP_724247.1  nessun dorma, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724247.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NP13, Q9VIP0
      Related
      FBpp0080866
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIP0.1 Q9VIP0

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