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    CG5446 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34655, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5446provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032429
    Locus tag
    Dmel_CG5446
    See related
    AllianceGenome:FB:FBgn0032429
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE36920; Dmel\CG5446
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in cellular heat acclimation. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including embryonic head epidermis; embryonic head sensory system; and sensory nervous system primordium. Orthologous to human HSBP1 (heat shock factor binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5446 in Genome Data Viewer
    Location:
    33E4-33E4; 2-46 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12426631..12427709, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12426631..12427709, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene virus-induced RNA 1 Neighboring gene Fam92 Neighboring gene tRNA methyltransferase 1 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene SR family splicing factor SC35

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental regulation of canonical and small ORF translation from mRNAs. Patraquim P, et al. Genome Biol, 2020 May 29. PMID 32471506, Free PMC Article
    2. The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila. Dostert C, et al. Nat Immunol, 2005 Sep. PMID 16086017
    3. Transcription of histone gene cluster by differential core-promoter factors. Isogai Y, et al. Genes Dev, 2007 Nov 15. PMID 17978101, Free PMC Article
    4. Transcriptional regulation by CHIP/LDB complexes. Bronstein R, et al. PLoS Genet, 2010 Aug 12. PMID 20730086, Free PMC Article
    5. Sequential activation of signaling pathways during innate immune responses in Drosophila. Boutros M, et al. Dev Cell, 2002 Nov. PMID 12431377

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular heat acclimation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5446-PA
    CG5446-PB
    CG5446-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12426631..12427709 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273485.1 → NP_001260414.1  uncharacterized protein Dmel_CG5446, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260414.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86C02, Q9VK90
      Conserved Domains (1) summary
      pfam06825
      Location:28 → 78
      HSBP1; Heat shock factor binding protein 1

    2. NM_001273484.1 → NP_001260413.1  uncharacterized protein Dmel_CG5446, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260413.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBA6
      Conserved Domains (1) summary
      pfam06825
      Location:34 → 72
      HSBP1; Heat shock factor binding protein 1

    3. NM_135721.3 → NP_609565.1  uncharacterized protein Dmel_CG5446, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609565.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86C02, Q9VK90
      Related
      FBpp0079969
      Conserved Domains (1) summary
      pfam06825
      Location:28 → 78
      HSBP1; Heat shock factor binding protein 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBA6 M9PBA6
    Q868A1 Q868A1
    Q86C01 Q86C01
    Q86C02 Q86C02
    Q8MYZ7 Q8MYZ7
    Q9VK90 Q9VK90

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