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    Ets21C Ets at 21C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33229, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ets21Cprovided by FlyBase
    Official Full Name
    Ets at 21Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0005660
    Locus tag
    Dmel_CG2914
    See related
    AllianceGenome:FB:FBgn0005660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2914; D-ets-6; D-Ets-6; D-Ets6; Dmel\CG2914; Ets; ets21c; ets21C; Ets21c; Ets6; ETS6
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in defense response to bacterium. Predicted to be active in nucleus. Is expressed in several structures, including embryonic brain; embryonic proventriculus; pars intercerebralis primordium; spermatozoon; and ventral nerve cord. Human ortholog(s) of this gene implicated in blood platelet disease; hereditary lymphedema; myeloid leukemia; and thrombocytopenia. Orthologous to human ERG (ETS transcription factor ERG) and FLI1 (Fli-1 proto-oncogene, ETS transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Ets21C in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (544925..552923, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (544925..552923, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lesswright Neighboring gene Signal peptide peptidase Neighboring gene nicotinic Acetylcholine Receptor beta3 Neighboring gene reduced mechanoreceptor potential A Neighboring gene uncharacterized nascent polypeptide-associated complex beta subunit Neighboring gene Translocator protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Circadian gene variants and the skeletal muscle circadian clock contribute to the evolutionary divergence in longevity across Drosophila populations. Hunt LC, et al. Genome Res, 2019 Aug. PMID 31249065, Free PMC Article
    2. Isolation and characterization of five Drosophila genes that encode an ets-related DNA binding domain. Chen T, et al. Dev Biol, 1992 May. PMID 1577186
    3. Longevity is determined by ETS transcription factors in multiple tissues and diverse species. Dobson AJ, et al. PLoS Genet, 2019 Jul. PMID 31356597, Free PMC Article
    4. scRNA-seq data from the larval Drosophila ventral cord provides a resource for studying motor systems function and development. Nguyen TH, et al. Dev Cell, 2024 May 6. PMID 38569548,
    5. A Drosophila model to study retinitis pigmentosa pathology associated with mutations in the core splicing factor Prp8. Stanković D, et al. Dis Model Mech, 2020 Jun 26. PMID 32424050, Free PMC Article

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hippo signaling promotes Ets21c-dependent apical cell extrusion in the Drosophila wing disc.
      Title: Hippo signaling promotes Ets21c-dependent apical cell extrusion in the Drosophila wing disc.
    2. Ets21c controls ISC proliferation as well as EC apoptosis through distinct sets of target genes that orchestrate cellular behaviors via intrinsic and non-autonomous signaling mechanisms.
      Title: Ets21c Governs Tissue Renewal, Stress Tolerance, and Aging in the Drosophila Intestine.
    3. Data show that Ets21C has a crucial role in the regulation of tumor growth as a loss of function critically reduced tumor growth, whereas an excess of Ets21C further increased tumor size. While Ets21C was shown only with a role in fine-tuning the transcriptional program of neoplastic tumors, results point towards a more fundamental role as activator of a specific set of target genes driving tumor growth and invasion.
      Title: The transcription factor Ets21C drives tumor growth by cooperating with AP-1.
    4. malignant transformation of the ras(V12)scrib(1) tumors requires bZIP protein Fos, the ETS-domain factor Ets21c and the nuclear receptor Ftz-F1, all acting downstream of Jun-N-terminal kinase.
      Title: Interplay among Drosophila transcription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy.
    5. These studies identify Cic, Pnt, and Ets21C as critical downstream effectors of EGFR signaling in Drosophila Intestinal Stem Cells
      Title: EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ets at 21C
    Names
    CG2914-PA
    CG2914-PB
    CG2914-PC
    CG2914-PD
    Ets21C-PA
    Ets21C-PB
    Ets21C-PC
    Ets21C-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      544925..552923 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298618.1 → NP_001285547.1  Ets at 21C, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285547.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29776, Q9VPQ9
      UniProtKB/TrEMBL
      A8E758
      Conserved Domains (2) summary
      cd08203
      Location:149 → 217
      SAM_PNT; Sterile alpha motif (SAM)/Pointed domain
      smart00413
      Location:254 → 339
      ETS; erythroblast transformation specific domain

    2. NM_001298619.1 → NP_001285548.1  Ets at 21C, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285548.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29776, Q9VPQ9
      UniProtKB/TrEMBL
      A8E758
      Conserved Domains (2) summary
      cd08203
      Location:149 → 217
      SAM_PNT; Sterile alpha motif (SAM)/Pointed domain
      smart00413
      Location:254 → 339
      ETS; erythroblast transformation specific domain

    3. NM_078721.2 → NP_523445.1  Ets at 21C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523445.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29776, Q9VPQ9
      UniProtKB/TrEMBL
      A8E758
      Related
      FBpp0077739
      Conserved Domains (2) summary
      cd08203
      Location:149 → 217
      SAM_PNT; Sterile alpha motif (SAM)/Pointed domain
      smart00413
      Location:254 → 339
      ETS; erythroblast transformation specific domain

    4. NM_001103577.3 → NP_001097047.1  Ets at 21C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097047.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYS7
      Conserved Domains (1) summary
      smart00413
      Location:84 → 169
      ETS; erythroblast transformation specific domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DYS7 A8DYS7
    A8E758 A8E758
    P29776.2 P29776

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