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    Sam-S S-adenosylmethionine Synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48552, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Sam-Sprovided by FlyBase
    Official Full Name
    S-adenosylmethionine Synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0005278
    Locus tag
    Dmel_CG2674
    See related
    AllianceGenome:FB:FBgn0005278
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2674; Dmel\CG2674; M(2)21A-B; m(2)21ab; M(2)21AB; METK; SAM; sams; Sams; SamS; Su(z)5
    Summary
    Predicted to enable methionine adenosyltransferase activity. Involved in S-adenosylmethionine biosynthetic process and determination of adult lifespan. Predicted to be active in cytosol. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; gonad; gut section; and mesoderm. Used to study amino acid metabolic disorder. Human ortholog(s) of this gene implicated in hypermethioninemia and lung cancer. Orthologous to human MAT1A (methionine adenosyltransferase 1A) and MAT2A (methionine adenosyltransferase 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sam-S in Genome Data Viewer
    Location:
    21B2-21B2; 2-0.5 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (106903..114432)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (106903..114432)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Zizimin-related Neighboring gene Cysteine rich with EGF like domains Neighboring gene Na[+]/H[+] hydrogen exchanger 1 Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) 15 kDa subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A minute mutant with suppressor effect on the eye-colour gene zeste in Drosophila melanogaster. Persson K. Hereditas, 1976. PMID 816760
    2. Molecular cloning of the S-adenosylmethionine synthetase gene in Drosophila melanogaster. Larsson J, et al. FEBS Lett, 1994 Apr 11. PMID 8150093
    3. Biosynthesis of S-adenosyl-methionine enhances aging-related defects in Drosophila oogenesis. Hayashi Y, et al. Sci Rep, 2022 Apr 4. PMID 35379840, Free PMC Article
    4. A complex interplay between SAM synthetase and the epigenetic regulator SIN3 controls metabolism and transcription. Liu M, et al. J Biol Chem, 2020 Jan 10. PMID 31776190, Free PMC Article
    5. Kynurenine Metabolism in the Fat Body Non-autonomously Regulates Imaginal Disc Repair in Drosophila. Kashio S, et al. iScience, 2020 Dec 18. PMID 33376969, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A complex interplay between SAM synthetase and the epigenetic regulator SIN3 controls metabolism and transcription.
      Title: A complex interplay between SAM synthetase and the epigenetic regulator SIN3 controls metabolism and transcription.
    2. Knockdown of SAM synthase shortened Drosophila lifespan.
      Title: Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine adenosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionine adenosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine adenosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in S-adenosylmethionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in S-adenosylmethionine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    S-adenosylmethionine synthetase
    Names
    CG2674-PA
    CG2674-PB
    CG2674-PC
    CG2674-PD
    CG2674-PE
    CG2674-PF
    CG2674-PG
    CG2674-PH
    CG2674-PI
    CG2674-PJ
    CG2674-PK
    CG2674-PL
    S-Adenosylmethionine synthetase
    SAM synthase
    Sam-S-PA
    Sam-S-PB
    Sam-S-PC
    Sam-S-PD
    Sam-S-PE
    Sam-S-PF
    Sam-S-PG
    Sam-S-PH
    Sam-S-PI
    Sam-S-PJ
    Sam-S-PK
    Sam-S-PL
    methionine adenosyl transferase
    minute (2) 21AB
    NP_001245814.1
    NP_001259791.1
    NP_524923.1
    NP_722593.1
    NP_722594.1
    NP_722595.1
    NP_722596.1
    NP_722597.1
    NP_722598.1
    NP_722599.1
    NP_722600.1
    NP_995602.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      106903..114432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_205880.1 → NP_995602.1  S-adenosylmethionine synthetase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995602.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P40320, Q0E8V3, Q9VPJ2, Q9VPJ3, Q9VPJ4, Q9VPJ5
      Conserved Domains (4) summary
      PTZ00104
      Location:28 → 408
      PTZ00104; S-adenosylmethionine synthase; Provisional
      pfam00438
      Location:28 → 125
      S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain
      pfam02772
      Location:140 → 261
      S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain
      pfam02773
      Location:263 → 399
      S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain

    2. NM_001272862.1 → NP_001259791.1  S-adenosylmethionine synthetase, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259791.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PAY2
      Conserved Domains (1) summary
      pfam00438
      Location:28 → 111
      S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain

    3. NM_164356.2 → NP_722594.1  S-adenosylmethionine synthetase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722594.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P40320, Q0E8V3, Q9VPJ2, Q9VPJ3, Q9VPJ4, Q9VPJ5
      Related
      FBpp0088445
      Conserved Domains (4) summary
      PTZ00104
      Location:28 → 408
      PTZ00104; S-adenosylmethionine synthase; Provisional
      pfam00438
      Location:28 → 125
      S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain
      pfam02772
      Location:140 → 261
      S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain
      pfam02773
      Location:263 → 399
      S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain

    4. NM_164361.2 → NP_722599.1  S-adenosylmethionine synthetase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722599.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P40320
      Related
      FBpp0088444
      Conserved Domains (1) summary
      PTZ00104
      Location:28 → 146
      PTZ00104; S-adenosylmethionine synthase; Provisional

    5. NM_001258885.2 → NP_001245814.1  S-adenosylmethionine synthetase, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245814.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E4NKH6
      Conserved Domains (1) summary
      pfam00438
      Location:28 → 109
      S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain

    6. NM_080184.2 → NP_524923.1  S-adenosylmethionine synthetase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524923.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4UZW2
      Related
      FBpp0088447
      Conserved Domains (4) summary
      PTZ00104
      Location:28 → 408
      PTZ00104; S-adenosylmethionine synthase; Provisional
      pfam00438
      Location:28 → 125
      S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain
      pfam02772
      Location:140 → 261
      S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain
      pfam02773
      Location:263 → 399
      S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain

    7. NM_164357.2 → NP_722595.1  S-adenosylmethionine synthetase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722595.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P40320, Q0E8V3, Q9VPJ2, Q9VPJ3, Q9VPJ4, Q9VPJ5
      Related
      FBpp0088446
      Conserved Domains (4) summary
      PTZ00104
      Location:28 → 408
      PTZ00104; S-adenosylmethionine synthase; Provisional
      pfam00438
      Location:28 → 125
      S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain
      pfam02772
      Location:140 → 261
      S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain
      pfam02773
      Location:263 → 399
      S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain

    8. NM_164359.2 → NP_722597.1  S-adenosylmethionine synthetase, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722597.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P40320, Q0E8V3, Q9VPJ2, Q9VPJ3, Q9VPJ4, Q9VPJ5
      Related
      FBpp0088448
      Conserved Domains (4) summary
      PTZ00104
      Location:28 → 408
      PTZ00104; S-adenosylmethionine synthase; Provisional
      pfam00438
      Location:28 → 125
      S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain
      pfam02772
      Location:140 → 261
      S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain
      pfam02773
      Location:263 → 399
      S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain

    9. NM_164358.2 → NP_722596.1  S-adenosylmethionine synthetase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722596.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P40320, Q0E8V3, Q9VPJ2, Q9VPJ3, Q9VPJ4, Q9VPJ5
      Related
      FBpp0088449
      Conserved Domains (4) summary
      PTZ00104
      Location:28 → 408
      PTZ00104; S-adenosylmethionine synthase; Provisional
      pfam00438
      Location:28 → 125
      S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain
      pfam02772
      Location:140 → 261
      S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain
      pfam02773
      Location:263 → 399
      S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain

    10. NM_164360.3 → NP_722598.1  S-adenosylmethionine synthetase, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722598.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P40320, Q0E8V3, Q9VPJ2, Q9VPJ3, Q9VPJ4, Q9VPJ5
      Related
      FBpp0088450
      Conserved Domains (4) summary
      PTZ00104
      Location:28 → 408
      PTZ00104; S-adenosylmethionine synthase; Provisional
      pfam00438
      Location:28 → 125
      S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain
      pfam02772
      Location:140 → 261
      S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain
      pfam02773
      Location:263 → 399
      S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain

    11. NM_164355.3 → NP_722593.1  S-adenosylmethionine synthetase, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722593.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4UZW2
      Related
      FBpp0088451
      Conserved Domains (4) summary
      PTZ00104
      Location:28 → 408
      PTZ00104; S-adenosylmethionine synthase; Provisional
      pfam00438
      Location:28 → 125
      S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain
      pfam02772
      Location:140 → 261
      S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain
      pfam02773
      Location:263 → 399
      S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain

    12. NM_164362.3 → NP_722600.1  S-adenosylmethionine synthetase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722600.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV92
      Related
      FBpp0088452
      Conserved Domains (4) summary
      PTZ00104
      Location:15 → 381
      PTZ00104; S-adenosylmethionine synthase; Provisional
      pfam00438
      Location:15 → 98
      S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain
      pfam02772
      Location:113 → 234
      S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain
      pfam02773
      Location:236 → 372
      S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4UZW2 A4UZW2
    E4NKH6 E4NKH6
    M9PAY2 M9PAY2
    P40320.2 P40320

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