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    vimar visceral mesodermal armadillo-repeats [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35609, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vimarprovided by FlyBase
    Official Full Name
    visceral mesodermal armadillo-repeatsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0022960
    Locus tag
    Dmel_CG3572
    See related
    AllianceGenome:FB:FBgn0022960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey213; CG3572; Dmel\CG3572; l(2)k16722; Vimar
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in muscle cell cellular homeostasis; regulation of mitochondrion organization; and rhabdomere development. Located in cytosol; endoplasmic reticulum; and mitochondrion. Is expressed in several structures, including adult head; adult mushroom body; larval muscle cell; synaptic neuropil domain; and visceral muscle primordium. Orthologous to human RAP1GDS1 (Rap1 GTPase-GDP dissociation stimulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See vimar in Genome Data Viewer
    Location:
    42E1-42E1; 2-55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6975285..6985712, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2862790..2873217, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene missing-in-metastasis Neighboring gene Chemosensory protein B 42c Neighboring gene pickpocket 25 Neighboring gene long non-coding RNA:CR44170 Neighboring gene long non-coding RNA:CR44171 Neighboring gene Cytochrome P450 6u1 Neighboring gene UFM1 specific peptidase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Tetraspanin 42Ea Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vimar/RAP1GDS1 promotes acceleration of brain aging after flies and mice reach middle age. Xiong Y, et al. Commun Biol, 2023 Apr 15. PMID 37061660, Free PMC Article
    2. bagpipe-Dependent expression of vimar, a novel Armadillo-repeats gene, in Drosophila visceral mesoderm. Lo PC, et al. Mech Dev, 1998 Mar. PMID 9533953
    3. Spaced training activates Miro/Milton-dependent mitochondrial dynamics in neuronal axons to sustain long-term memory. Pavlowsky A, et al. Curr Biol, 2024 May 6. PMID 38642548
    4. Vimar Is a Novel Regulator of Mitochondrial Fission through Miro. Ding L, et al. PLoS Genet, 2016 Oct. PMID 27716788, Free PMC Article
    5. A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila. Bodmer R, et al. Development, 1990 Nov. PMID 1982429

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in muscle cell cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in muscle cell cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitochondrion organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in rhabdomere development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    visceral mesodermal armadillo-repeats
    Names
    CG3572-PB
    CG3572-PC
    vimar-PB
    vimar-PC
    visceral mesoderm armadillo repeats
    visceral mesodermal armadillo repeats

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6975285..6985712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057957.5 → NP_477305.1  visceral mesodermal armadillo-repeats, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477305.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6S6
      Related
      FBpp0089175
      Conserved Domains (2) summary
      cd00020
      Location:321 → 427
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:76 → 117
      ARM; armadillo repeat [structural motif]

    2. NM_206045.2 → NP_995767.1  visceral mesodermal armadillo-repeats, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995767.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z6S6, A1Z6S7, O44116, Q86LF4, Q8T996
      Conserved Domains (2) summary
      cd00020
      Location:322 → 428
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:77 → 118
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z6S7.1 A1Z6S7

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