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    CG17683 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355011, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG17683provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262115
    Locus tag
    Dmel_CG17683
    See related
    AllianceGenome:FB:FBgn0262115
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG17683; l(2)NC37; l(2)NC38; l(2)NC70; lop1; NAR1p; NC37; NC38; NC70
    Summary
    Predicted to be involved in iron-sulfur cluster assembly. Predicted to be part of cytosolic [4Fe-4S] assembly targeting complex. Orthologous to several human genes including CIAO3 (cytosolic iron-sulfur assembly component 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG17683 in Genome Data Viewer
    Location:
    41A1-41A1; 2-55 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (4130974..4133484)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18479..20989)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45139 Neighboring gene unextended Neighboring gene haspin Neighboring gene Ribonuclease kappa Neighboring gene Integrator 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. Coulthard AB, et al. Genetics, 2010 Jun. PMID 20382826, Free PMC Article
    2. Modulation of Heterochromatin by Male Specific Lethal Proteins and roX RNA in Drosophila melanogaster Males. Koya SK, et al. PLoS One, 2015. PMID 26468879, Free PMC Article
    3. Glial ferritin maintains neural stem cells via transporting iron required for self-renewal in Drosophila. Ma Z, et al. Elife, 2024 Sep 10. PMID 39255019, Free PMC Article
    4. Genetic and bioinformatic analysis of 41C and the 2R heterochromatin of Drosophila melanogaster: a window on the heterochromatin-euchromatin junction. Myster SH, et al. Genetics, 2004 Feb. PMID 15020470, Free PMC Article
    5. Genes for iron metabolism influence circadian rhythms in Drosophila melanogaster. Mandilaras K, et al. Metallomics, 2012 Aug. PMID 22885802

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic [4Fe-4S] assembly targeting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG17683-PA
    CG17683-PC
    CG17683-PD
    CG17683-PE
    lethal (2) NC37
    lethal (2) NC38
    lethal (2) NC70

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      4130974..4133484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042964.2 → NP_001036429.1  uncharacterized protein Dmel_CG17683, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036429.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5AEK9
      Conserved Domains (3) summary
      smart00902
      Location:372 → 418
      Fe_hyd_SSU; Iron hydrogenase small subunit
      COG4624
      Location:11 → 417
      Nar1; Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]
      pfam02906
      Location:64 → 359
      Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain

    2. NM_001042962.2 → NP_001036427.1  uncharacterized protein Dmel_CG17683, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036427.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SYS7
      Conserved Domains (2) summary
      smart00902
      Location:238 → 284
      Fe_hyd_SSU; Iron hydrogenase small subunit
      pfam02906
      Location:1 → 225
      Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain

    3. NM_001042965.2 → NP_001036430.1  uncharacterized protein Dmel_CG17683, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036430.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NHB7
      Conserved Domains (3) summary
      smart00902
      Location:415 → 461
      Fe_hyd_SSU; Iron hydrogenase small subunit
      COG4624
      Location:25 → 460
      Nar1; Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]
      pfam02906
      Location:107 → 402
      Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain

    4. NM_001042963.2 → NP_001036428.1  uncharacterized protein Dmel_CG17683, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036428.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5LJW9, Q5LJX0, Q7PLS3, Q8SYS7
      Conserved Domains (3) summary
      smart00902
      Location:419 → 465
      Fe_hyd_SSU; Iron hydrogenase small subunit
      COG4624
      Location:29 → 464
      Nar1; Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]
      pfam02906
      Location:111 → 406
      Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYS7.1 Q8SYS7

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