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    SP1029 SP1029 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53473, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SP1029provided by FlyBase
    Official Full Name
    SP1029provided by FlyBase
    Primary source
    FLYBASE:FBgn0263236
    Locus tag
    Dmel_CG11956
    See related
    AllianceGenome:FB:FBgn0263236
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11956; Dmel\CG11956; ptl; ptls; Sp1029
    Summary
    Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in several structures, including adult head; embryonic head epidermis; embryonic maxillary sensory complex; embryonic ventral epidermis; and epithelium. Orthologous to human ANPEP (alanyl aminopeptidase, membrane). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SP1029 in Genome Data Viewer
    Location:
    99A4-99A5; 3-98 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29244961..29250451, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25070683..25076173, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene string Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cis-regulatory elements of the mitotic regulator, string/Cdc25. Lehman DA, et al. Development, 1999 May. PMID 10101114, Free PMC Article
    2. Genetic analysis of dPsa, the Drosophila orthologue of puromycin-sensitive aminopeptidase, suggests redundancy of aminopeptidases. Schulz C, et al. Dev Genes Evol, 2001 Dec. PMID 11819115
    3. Transcriptional regulation of string (cdc25): a link between developmental programming and the cell cycle. Edgar BA, et al. Development, 1994 Nov. PMID 7720557, Free PMC Article
    4. Genome-wide identification and comparative analysis of Cry toxin receptor families in 7 insect species with a focus on Spodoptera litura. Li Q, et al. Insect Sci, 2022 Jun. PMID 34405540
    5. Specific transcriptional responses to juvenile hormone and ecdysone in Drosophila. Beckstead RB, et al. Insect Biochem Mol Biol, 2007 Jun. PMID 17517334, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SP1029
    Names
    CG11956-PA
    CG11956-PB
    CG11956-PC
    CG11956-PD
    CG11956-PE
    SP1029-PA
    SP1029-PB
    SP1029-PC
    SP1029-PD
    SP1029-PE
    pathless

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29244961..29250451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_144361.2 → NP_652618.1  SP1029, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652618.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KI00, Q6IDH1, Q9NH67
      Related
      FBpp0084767
      Conserved Domains (3) summary
      cd09601
      Location:43 → 502
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:33 → 431
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:583 → 908
      ERAP1_C; ERAP1-like C-terminal domain

    2. NM_170405.2 → NP_733284.1  SP1029, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733284.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KI00, Q6IDH1, Q9NH67
      Related
      FBpp0084768
      Conserved Domains (3) summary
      cd09601
      Location:43 → 502
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:33 → 431
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:583 → 908
      ERAP1_C; ERAP1-like C-terminal domain

    3. NM_001276136.1 → NP_001263065.1  SP1029, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263065.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KI00, Q6IDH1, Q9NH67
      Conserved Domains (3) summary
      cd09601
      Location:43 → 502
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:33 → 431
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:583 → 908
      ERAP1_C; ERAP1-like C-terminal domain

    4. NM_001300651.1 → NP_001287580.1  SP1029, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287580.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KI00, Q6IDH1, Q9NH67
      Conserved Domains (3) summary
      cd09601
      Location:43 → 502
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:33 → 431
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:583 → 908
      ERAP1_C; ERAP1-like C-terminal domain

    5. NM_170406.2 → NP_733285.1  SP1029, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733285.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KI00, Q6IDH1, Q9NH67
      Related
      FBpp0084769
      Conserved Domains (3) summary
      cd09601
      Location:43 → 502
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:33 → 431
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:583 → 908
      ERAP1_C; ERAP1-like C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0KI00 Q0KI00
    Q960U1 Q960U1
    Q9NH67 Q9NH67

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