Moca-cyp Moca-cyp [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Moca-cypprovided by FlyBase
Official Full Name: Moca-cypprovided by FlyBase
Primary source: FLYBASE:FBgn0039581
Locus tag: Dmel_CG1866
See related: AllianceGenome:FB:FBgn0039581
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0147981.13; anon-WO0147981.4; anon-WO0147981.5; BEST:LD38313; CG1866; Dmel\CG1866; moca
Summary: Enables peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Located in nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including adult brain cell body rind; adult head; embryonic/larval midgut primordium; ganglia; and gut section. Orthologous to several human genes including PPIG (peptidylprolyl isomerase G). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 98C4-98C4; 3-95 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (28340334..28345169)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (24166056..24170891)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cloning, characterization, and sequencing
Title: Identification and characterization of Moca-cyp. A Drosophila melanogaster nuclear cyclophilin.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cyclosporin A binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein peptidyl-prolyl isomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of precatalytic spliceosome	HDA more info	PubMed

General protein information

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Preferred Names: Moca-cyp

Names: CG1866-PA; CG1866-PB; CG1866-PC; Moca-cyp-PA; Moca-cyp-PB; Moca-cyp-PC

NP_001163758.1

EC 5.2.1.8

NP_651618.3

EC 5.2.1.8

NP_733246.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

28340334..28345169

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001170287.3 → NP_001163758.1 Moca-cyp, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163758.1

Status: REVIEWED

UniProtKB/TrEMBL

Q961G9, Q9VAW2

Conserved Domains (1) summary

PRK12678
Location:327 → 519

PRK12678; transcription termination factor Rho; Provisional
NM_143361.6 → NP_651618.3 Moca-cyp, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651618.3

Status: REVIEWED

UniProtKB/TrEMBL

Q961G9, Q9VAW2

Related

FBpp0084656

Conserved Domains (1) summary

PRK12678
Location:327 → 519

PRK12678; transcription termination factor Rho; Provisional
NM_170367.3 → NP_733246.1 Moca-cyp, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733246.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8ISE5, Q9VAW1

Related

FBpp0084655

Conserved Domains (2) summary

pfam16609
Location:635 → 718

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cl00197
Location:13 → 180

cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...