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    E(spl)m4-BFM Enhancer of split m4, Bearded family member [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43157, updated on 9-Dec-2024

    Summary

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    Official Symbol
    E(spl)m4-BFMprovided by FlyBase
    Official Full Name
    Enhancer of split m4, Bearded family memberprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002629
    Locus tag
    Dmel_CG6099
    See related
    AllianceGenome:FB:FBgn0002629
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6099; DmelCG6099; Dmel\CG6099; E(spl) m4; E(spl)m4; HLHm4; m4
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in cell fate specification; negative regulation of Notch signaling pathway; and sensory organ development. Is expressed in several structures, including embryonic optic lobe primordium; epithelium; germ layer; hindgut proper primordium; and imaginal disc. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See E(spl)m4-BFM in Genome Data Viewer
    Location:
    96F10-96F10; 3-89 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26023821..26024579, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21849543..21850301, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43644 Neighboring gene Enhancer of split m3, helix-loop-helix Neighboring gene Enhancer of split m5, helix-loop-helix Neighboring gene Enhancer of split m6, Bearded family member

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Bearded box, a novel 3' UTR sequence motif, mediates negative post-transcriptional regulation of Bearded and Enhancer of split Complex gene expression. Lai EC, et al. Development, 1997 Dec. PMID 9428421
    2. Seven genes of the Enhancer of split complex of Drosophila melanogaster encode helix-loop-helix proteins. Knust E, et al. Genetics, 1992 Oct. PMID 1427040, Free PMC Article
    3. Ancestral and conserved cis-regulatory architectures in developmental control genes. Rebeiz M, et al. Dev Biol, 2012 Feb 15. PMID 22185795, Free PMC Article
    4. Lateral inhibition: Two modes of non-autonomous negative autoregulation by neuralized. Miller SW, et al. PLoS Genet, 2018 Jul. PMID 30028887, Free PMC Article
    5. Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster. Delidakis C, et al. Genetics, 1991 Nov. PMID 1752423, Free PMC Article

    See all (118) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    enhancer of split m4, bearded family member
    Names
    CG6099-PA
    E(spl) region transcript 4
    E(spl) region transcript m4
    E(spl)m4-BFM-PA
    enhancer of split m4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26023821..26024579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079786.3 → NP_524510.1  enhancer of split m4, bearded family member [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524510.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P13095, Q56L08, Q56L11, Q56L12, Q56L19, Q56L29, Q56L35, Q56L44, Q56L45, Q56L64, Q56L67, Q56L68, Q56L69, Q56L92, Q5S478, Q5S4B4, Q5S4J8, Q9VBI9
      UniProtKB/TrEMBL
      A0A1B2AJV0, D5SHS0
      Related
      FBpp0084353
      Conserved Domains (1) summary
      pfam15952
      Location:1 → 152
      ESM4; Enhancer of split M4 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13095.1 P13095

    Gene LinkOut

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