U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    msi musashi [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43087, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    msiprovided by FlyBase
    Official Full Name
    musashiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011666
    Locus tag
    Dmel_CG5099
    See related
    AllianceGenome:FB:FBgn0011666
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    3R11; anon-EST:Liang-2.35; CG5099; clone 2.35; Dmel\CG5099; dMsi; dMSI; DMSIDNA; Msi; MSI; SIDNA
    Summary
    Predicted to enable mRNA binding activity. Involved in several processes, including cellular response to hypoxia; compound eye photoreceptor fate commitment; and germ-line stem cell division. Located in nucleus. Is expressed in several structures, including adult brain; lamina; larval nervous system; mechanosensory chaeta; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See msi in Genome Data Viewer
    Location:
    96E2-96E4; 3-88 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25516118..25608423)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21341840..21434145)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46100 Neighboring gene long non-coding RNA:CR45910 Neighboring gene uncharacterized protein Neighboring gene mir-1000 stem loop Neighboring gene yellow-emperor Neighboring gene uncharacterized protein Neighboring gene Nuclear protein localization 4 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. MiMIC analysis reveals an isoform specific role for Drosophila Musashi in follicle stem cell maintenance and escort cell function. Siddall NA, et al. Cell Death Discov, 2022 Nov 12. PMID 36371343, Free PMC Article
    2. A conserved three-nucleotide core motif defines Musashi RNA binding specificity. Zearfoss NR, et al. J Biol Chem, 2014 Dec 19. PMID 25368328, Free PMC Article
    3. The origin of the Jingwei gene and the complex modular structure of its parental gene, yellow emperor, in Drosophila melanogaster. Wang W, et al. Mol Biol Evol, 2000 Sep. PMID 10958846
    4. Dueling RNA-binding proteins promote translational activation. Lasko P. Nat Struct Mol Biol, 2017 Aug 3. PMID 28771463
    5. The RNA-binding protein Musashi controls axon compartment-specific synaptic connectivity through ptp69D mRNA poly(A)-tailing. Landínez-Macías M, et al. Cell Rep, 2021 Sep 14. PMID 34525368

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The RNA-binding protein Musashi controls axon compartment-specific synaptic connectivity through ptp69D mRNA poly(A)-tailing.
      Title: The RNA-binding protein Musashi controls axon compartment-specific synaptic connectivity through ptp69D mRNA poly(A)-tailing.
    2. Musashi expression in intestinal stem cells attenuates radiation-induced decline in intestinal permeability and survival in Drosophila.
      Title: Musashi expression in intestinal stem cells attenuates radiation-induced decline in intestinal permeability and survival in Drosophila.
    3. The juxtaposition of RNA motifs enables cooperative regulation by CPEB1 and Msi1.
      Title: Dueling RNA-binding proteins promote translational activation.
    4. show specific evidence for a cell-autonomous requirement for Msi family proteins in regulating stem cell differentiation, leading to the identification of an RNA-binding protein required for spermatogonial stem cell maintenance
      Title: The RNA-binding protein Musashi is required intrinsically to maintain stem cell identity.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables mRNA regulatory element binding translation repressor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables translation regulator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell fate determination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chaeta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye photoreceptor fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-line stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    musashi
    Names
    CG5099-PA
    CG5099-PB
    CG5099-PC
    CG5099-PD
    CG5099-PE
    CG5099-PF
    CG5099-PH
    msi-PA
    msi-PB
    msi-PC
    msi-PD
    msi-PE
    msi-PF
    msi-PH
    mushashi

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25516118..25608423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276031.1 → NP_001262960.1  musashi, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262960.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMS8, Q8MS04
      Conserved Domains (2) summary
      cd12323
      Location:292 → 365
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12325
      Location:205 → 276
      RRM1_hnRNPA_hnRNPD_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP A and hnRNP D subfamilies and similar proteins

    2. NM_001260374.2 → NP_001247303.1  musashi, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247303.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMS8, Q8MS04
      Conserved Domains (2) summary
      cd12323
      Location:292 → 365
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12325
      Location:205 → 276
      RRM1_hnRNPA_hnRNPD_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP A and hnRNP D subfamilies and similar proteins

    3. NM_001276030.1 → NP_001262959.1  musashi, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262959.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHV4, Q8MS04
      Conserved Domains (2) summary
      cd12323
      Location:276 → 349
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12325
      Location:189 → 260
      RRM1_hnRNPA_hnRNPD_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP A and hnRNP D subfamilies and similar proteins

    4. NM_001260375.2 → NP_001247304.1  musashi, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247304.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6K8, Q8MS04
      Conserved Domains (2) summary
      cd12323
      Location:263 → 336
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12325
      Location:176 → 247
      RRM1_hnRNPA_hnRNPD_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP A and hnRNP D subfamilies and similar proteins

    5. NM_170229.3 → NP_733108.2  musashi, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733108.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMS8, Q8MS04
      Related
      FBpp0084255
      Conserved Domains (2) summary
      cd12323
      Location:292 → 365
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12325
      Location:205 → 276
      RRM1_hnRNPA_hnRNPD_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP A and hnRNP D subfamilies and similar proteins

    6. NM_001276032.1 → NP_001262961.1  musashi, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262961.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGY9, D0Z767
      Conserved Domains (2) summary
      cd12323
      Location:225 → 298
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12325
      Location:138 → 209
      RRM1_hnRNPA_hnRNPD_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP A and hnRNP D subfamilies and similar proteins

    7. NM_079838.4 → NP_524577.1  musashi, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524577.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0Z767, Q24409, Q9U970, Q9VBQ1
      Related
      FBpp0084256
      Conserved Domains (2) summary
      cd12323
      Location:264 → 337
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12325
      Location:177 → 248
      RRM1_hnRNPA_hnRNPD_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP A and hnRNP D subfamilies and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6K8 A0A0B4K6K8
    A0A0B4KGY9 A0A0B4KGY9
    A0A0B4KHV4 A0A0B4KHV4
    Q7JN15 Q7JN15
    Q86PA1 Q86PA1
    Q8IMS8 Q8IMS8
    Q8MS04 Q8MS04
    Q9VBQ1 Q9VBQ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous