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    beta-PheRS Phenylalanyl-tRNA synthetase, beta-subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42888, updated on 9-Dec-2024

    Summary

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    Official Symbol
    beta-PheRSprovided by FlyBase
    Official Full Name
    Phenylalanyl-tRNA synthetase, beta-subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039175
    Locus tag
    Dmel_CG5706
    See related
    AllianceGenome:FB:FBgn0039175
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5706; Dmel\CG5706
    Summary
    Enables aminoacyl-tRNA editing activity and phenylalanine-tRNA ligase activity. Involved in phenylalanyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be part of phenylalanine-tRNA ligase complex. Is expressed in embryonic/larval midgut and organism. Orthologous to human FARSB (phenylalanyl-tRNA synthetase subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See beta-PheRS in Genome Data Viewer
    Location:
    95F5-95F6; 3-84 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24250460..24252679, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20076182..20078401, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45217 Neighboring gene long non-coding RNA:CR44092 Neighboring gene small Cajal body-specific RNA : MeU2-G25 Neighboring gene multiple ankyrin repeats single KH domain Neighboring gene jaguar Neighboring gene transfer RNA:Leucine-TAA 4-1 Neighboring gene Organic cation transporter 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic characterization of the Drosophila jaguar322 mutant reveals that complete myosin VI loss of function is not lethal. Morrison JK, et al. Genetics, 2008 May. PMID 18493084, Free PMC Article
    2. Effects of unstable β-PheRS on food avoidance, growth, and development are suppressed by the appetite hormone CCHa2. Brunßen D, et al. Fly (Austin), 2024 Dec. PMID 38374657, Free PMC Article
    3. Double-sieving-defective aminoacyl-tRNA synthetase causes protein mistranslation and affects cellular physiology and development. Lu J, et al. Nat Commun, 2014 Nov 27. PMID 25427601, Free PMC Article
    4. A translation-independent function of PheRS activates growth and proliferation in Drosophila. Ho MT, et al. Dis Model Mech, 2021 Mar 18. PMID 33547043, Free PMC Article
    5. The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. Petritsch C, et al. Dev Cell, 2003 Feb. PMID 12586070

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effects of unstable beta-PheRS on food avoidance, growth, and development are suppressed by the appetite hormone CCHa2.
      Title: Effects of unstable β-PheRS on food avoidance, growth, and development are suppressed by the appetite hormone CCHa2.
    2. Knockout of alpha-PheRS (CG2263) and beta-PheRS (CG5706) causes protein mistranslation and affects cellular physiology and development.
      Title: Double-sieving-defective aminoacyl-tRNA synthetase causes protein mistranslation and affects cellular physiology and development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phenylalanine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phenylalanine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phenylalanine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phenylalanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phenylalanyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phenylalanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phenylalanyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of phenylalanine-tRNA ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Phenylalanyl-tRNA synthetase, beta-subunit
    Names
    CG5706-PA
    Phenylalanyl-tRNA synthetase beta subunit
    beta-PheRS-PA
    NP_651237.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24250460..24252679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142980.4 → NP_651237.1  Phenylalanyl-tRNA synthetase, beta-subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651237.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VCA5
      Related
      FBpp0084021
      Conserved Domains (4) summary
      smart00873
      Location:118 → 279
      B3_4; B3/4 domain
      PLN02265
      Location:1 → 589
      PLN02265; probable phenylalanyl-tRNA synthetase beta chain
      cd00769
      Location:390 → 588
      PheRS_beta_core; Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an ...
      pfam03484
      Location:310 → 372
      B5; tRNA synthetase B5 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCA5.1 Q9VCA5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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