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    wda will decrease acetylation [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42750, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wdaprovided by FlyBase
    Official Full Name
    will decrease acetylationprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039067
    Locus tag
    Dmel_CG4448
    See related
    AllianceGenome:FB:FBgn0039067
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4448; Dmel\CG4448; dWda; Wda; WDA; WFA
    Summary
    Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of SAGA complex. Orthologous to human TAF5L (TATA-box binding protein associated factor 5 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See wda in Genome Data Viewer
    Location:
    94E9-94E9; 3-78 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23255070..23258087, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19080792..19083809, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rad60 Neighboring gene Elongin A Neighboring gene Peroxin 11c Neighboring gene oo18 RNA-binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NetREX-CF integrates incomplete transcription factor data with gene expression to reconstruct gene regulatory networks. Wang Y, et al. Commun Biol, 2022 Nov 23. PMID 36418514, Free PMC Article
    2. The SAGA core module is critical during Drosophila oogenesis and is broadly recruited to promoters. Soffers JHM, et al. PLoS Genet, 2021 Nov. PMID 34807910, Free PMC Article
    3. Insights into SAGA function during gene expression. Rodríguez-Navarro S. EMBO Rep, 2009 Aug. PMID 19609321, Free PMC Article
    4. The essential gene wda encodes a WD40 repeat subunit of Drosophila SAGA required for histone H3 acetylation. Guelman S, et al. Mol Cell Biol, 2006 Oct. PMID 16980620, Free PMC Article
    5. Loss of Drosophila Ataxin-7, a SAGA subunit, reduces H2B ubiquitination and leads to neural and retinal degeneration. Mohan RD, et al. Genes Dev, 2014 Feb 1. PMID 24493646, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results point to a critical function of dSAGA and histone acetylation during Drosophila development.
      Title: The essential gene wda encodes a WD40 repeat subunit of Drosophila SAGA required for histone H3 acetylation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    will decrease acetylation
    Names
    CG4448-PA
    wda-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23255070..23258087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142879.3 → NP_651136.1  will decrease acetylation [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651136.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCN9
      Related
      FBpp0083779
      Conserved Domains (4) summary
      COG2319
      Location:324 → 700
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:491 → 700
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:501 → 537
      7WD40; WD40 repeat [structural motif]
      cl08418
      Location:104 → 273
      TAF5_NTD2; TAF5_NTD2 is the second conserved N-terminal region of TATA Binding Protein (TBP) Associated Factor 5 (TAF5), involved in forming Transcription Factor IID (TFIID)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCN9 Q9VCN9

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