Gclm Glutamate-cysteine ligase modifier subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gclmprovided by FlyBase
Official Full Name: Glutamate-cysteine ligase modifier subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0046114
Locus tag: Dmel_CG4919
See related: AllianceGenome:FB:FBgn0046114
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 4919; box; CG4919; Dmel\CG4919; DmGCLM; DmGCSl; gclm; gclM; GCLm; GCLM; Gcsl; GCSl
Summary: Enables glutamate-cysteine ligase catalytic subunit binding activity and glutamate-cysteine ligase regulator activity. Involved in several processes, including behavioral response to ethanol; detoxification of arsenic-containing substance; and glutathione biosynthetic process. Located in cytosol. Part of glutamate-cysteine ligase complex. Is expressed in adult head; embryonic midgut chamber; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (22685006..22686510, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (18510728..18512232, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

overexpression of GCLm extended the mean life span only up to 24%
Title: Overexpression of glutamate-cysteine ligase extends life span in Drosophila melanogaster.
investigation of mutations in GCL modifier subunit and the GCL catalytic subunit that modify catalytic activity and lower glutathione levels
Title: The modifier subunit of Drosophila glutamate-cysteine ligase regulates catalytic activity by covalent and noncovalent interactions and influences glutathione homeostasis in vivo.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables glutamate-cysteine ligase catalytic subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate-cysteine ligase catalytic subunit binding	IEA Inferred from Electronic Annotation more info
enables glutamate-cysteine ligase catalytic subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables glutamate-cysteine ligase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate-cysteine ligase regulator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detoxification of arsenic-containing substance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glutathione biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glutathione biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glutathione biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of glutamate-cysteine ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of glutamate-cysteine ligase complex	IPI Inferred from Physical Interaction more info	PubMed

Names: CG4919-PA; CG4919-PB; Gclm-PA; Gclm-PB; gamma-Glutamylcysteine synthetase regulatory subunit

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The following sections contain reference sequences that belong to a specific genome build. Explain