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    CG4686 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42361, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4686provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038739
    Locus tag
    Dmel_CG4686
    See related
    AllianceGenome:FB:FBgn0038739
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT09463; Dmel\CG4686
    Summary
    Predicted to be active in membrane. Is expressed in adult head; adult heart; eye; and spermatozoon. Orthologous to human TMEM256 (transmembrane protein 256). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4686 in Genome Data Viewer
    Location:
    92B4-92B4; 3-67 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19864496..19866869)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15690218..15692591)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Mitochondrial calcium uptake 3 Neighboring gene Inositol-requiring enzyme-1 Neighboring gene Mitochondrial rRNA methyltransferase 2 Neighboring gene uncharacterized protein Neighboring gene Multidrug resistance protein 5 Neighboring gene uncharacterized protein Neighboring gene Activator-recruited cofactor subunit 42

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila. Muerdter F, et al. Mol Cell, 2013 Jun 6. PMID 23665228, Free PMC Article
    2. A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen. Xu H, et al. EMBO J, 2004 Feb 25. PMID 14963491, Free PMC Article
    3. Spitz from the retina regulates genes transcribed in the second mitotic wave, peripodial epithelium, glia and plasmatocytes of the Drosophila eye imaginal disc. Firth LC, et al. Dev Biol, 2007 Jul 15. PMID 17553483, Free PMC Article
    4. Genome-wide analyses of Shavenbaby target genes reveals distinct features of enhancer organization. Menoret D, et al. Genome Biol, 2013 Aug 23. PMID 23972280, Free PMC Article
    5. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4686-PA
    CG4686-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19864496..19866869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142580.3 → NP_650837.1  uncharacterized protein Dmel_CG4686, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650837.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP44, Q9VDT4
      Related
      FBpp0083226
      Conserved Domains (2) summary
      pfam04241
      Location:85 → 170
      DUF423; Protein of unknown function (DUF423)
      cl00192
      Location:24 → 114
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...

    2. NM_001275815.1 → NP_001262744.1  uncharacterized protein Dmel_CG4686, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262744.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP44, Q9VDT4
      Conserved Domains (2) summary
      pfam04241
      Location:85 → 170
      DUF423; Protein of unknown function (DUF423)
      cl00192
      Location:24 → 114
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDT4 Q9VDT4

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