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    c(3)G crossover suppressor on 3 of Gowen [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47765, updated on 17-Dec-2024

    Summary

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    Official Symbol
    c(3)Gprovided by FlyBase
    Official Full Name
    crossover suppressor on 3 of Gowenprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000246
    Locus tag
    Dmel_CG17604
    See related
    AllianceGenome:FB:FBgn0000246
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c(3)g; C(3)G; c3G; C3G; CG17604; cx; Dmel\CG17604
    Summary
    Predicted to enable actin filament binding activity. Involved in reciprocal meiotic recombination and synaptonemal complex assembly. Located in synaptonemal complex. Is expressed in several structures, including fat body/gonad primordium; female germline cyst; germline cell; gonad; and pole plasm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See c(3)G in Genome Data Viewer
    Location:
    89A5-89A5; 3-58 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15789473..15792579, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11615195..11618301, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Uroporphyrinogen III synthase 2 Neighboring gene Acylphosphatase 2 Neighboring gene non-specific lethal 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutagen sensitivity of wild type and recombination deficient c(3)G strains of Drosophila melanogaster. Würgler FE, et al. Arch Genet (Zur), 1978. PMID 121955
    2. An enhancement of the yield of X-ray-induced Minute mutations in the c3G female-ywmf-2 male system of Drosophila melanogaster. Miyamoto T. Mutat Res, 1992 Dec. PMID 1383800
    3. X-ray induced mitotic recombination in Drosophila melanogaster. 3. Dose dependence of the "pairing" component. Haendle J. Mol Gen Genet, 1974 Feb 6. PMID 4209669
    4. Chromosome segregation influenced by two alleles of the meiotic mutant c(3)G in Drosophila melanogaster. Hall JC. Genetics, 1972 Jul. PMID 4624918
    5. The synaptonemal complex has liquid crystalline properties and spatially regulates meiotic recombination factors. Rog O, et al. Elife, 2017 Jan 3. PMID 28045371, Free PMC Article

    See all (163) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. model of synaptonemal complex structure in which C(2)M links C(3)G to the lateral elements
      Title: Juxtaposition of C(2)M and the transverse filament protein C(3)G within the central region of Drosophila synaptonemal complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptonemal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    crossover suppressor on 3 of gowen
    Names
    CG17604-PA
    CG17604-PB
    CG17604-PC
    c(3)G-PA
    c(3)G-PB
    c(3)G-PC
    crossover suppressor in chromosome 3 of gowen
    crossover suppressor on 3 of gowan

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15789473..15792579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142233.3 → NP_650490.1  crossover suppressor on 3 of gowen, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650490.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6UVN4, B6UVQ1, Q9VF37
      Related
      FBpp0082648
      Conserved Domains (1) summary
      cl23765
      Location:363 → 516
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    2. NM_169671.3 → NP_732066.1  crossover suppressor on 3 of gowen, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732066.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6UVN4, B6UVQ1, Q9VF37
      Related
      FBpp0082650
      Conserved Domains (1) summary
      cl23765
      Location:363 → 516
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    3. NM_169670.3 → NP_732065.1  crossover suppressor on 3 of gowen, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732065.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6UVN4, B6UVQ1, Q9VF37
      Related
      FBpp0082649
      Conserved Domains (1) summary
      cl23765
      Location:363 → 516
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MQK7 Q8MQK7
    Q8SXH0 Q8SXH0
    Q9VF37 Q9VF37

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