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    Spec2 Spec2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40685, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Spec2provided by FlyBase
    Official Full Name
    Spec2provided by FlyBase
    Primary source
    FLYBASE:FBgn0044823
    Locus tag
    Dmel_CG14672
    See related
    AllianceGenome:FB:FBgn0044823
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD24607; CG14672; Dmel\CG14672; dSPEC; dSPEC2; Spec; SPEC; SPEC2
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in regulation of Rho protein signal transduction. Predicted to be located in cell cortex. Predicted to be active in plasma membrane. Is expressed in several structures, including embryonic hypopharynx; embryonic/larval midgut; embryonic/larval posterior spiracle; and ganglia. Orthologous to several human genes including CDC42SE2 (CDC42 small effector 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See Spec2 in Genome Data Viewer
    Location:
    83B6-83B6; 3-47.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5616644..5624125, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Antisense transcript of Rga Neighboring gene Regena Neighboring gene stable intronic sequence RNA 1 Neighboring gene antisense RNA:CR46135 Neighboring gene Another transcription unit Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Diphthamide biosynthesis 4 Neighboring gene Ribosomal protein L13A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NT_033777.3 Chromosome 3R Reference Release 6 plus ISO1 MT Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SPECs, small binding proteins for Cdc42. Pirone DM, et al. J Biol Chem, 2000 Jul 28. PMID 10816584
    2. Evolutionary expansion of CRIB-containing Cdc42 effector proteins. Pirone DM, et al. Trends Genet, 2001 Jul. PMID 11418196
    3. Specification of Dendritogenesis Site in Drosophila aCC Motoneuron by Membrane Enrichment of Pak1 through Dscam1. Kamiyama D, et al. Dev Cell, 2015 Oct 12. PMID 26460947, Free PMC Article
    4. Dominant suppressor genes of p53-induced apoptosis in Drosophila melanogaster. Szlanka T, et al. G3 (Bethesda), 2024 Sep 4. PMID 38985658, Free PMC Article
    5. Activin signaling targeted by insulin/dFOXO regulates aging and muscle proteostasis in Drosophila. Bai H, et al. PLoS Genet, 2013 Nov. PMID 24244197, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Spec2
    Names
    CG14672-PA
    Spec2-PA
    small protein effector of Cdc42 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5616644..5624125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169081.4 → NP_730968.1  Spec2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730968.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95T20, Q9VNE7
      UniProtKB/TrEMBL
      A0A1B2AJ56
      Related
      FBpp0078388
      Conserved Domains (1) summary
      cd00132
      Location:35 → 75
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VNE7.2 Q9VNE7

    Gene LinkOut

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    Other Literature Sources
    Molecular Biology Databases