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    Tob Transducer of ERBB2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32574, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tobprovided by FlyBase
    Official Full Name
    Transducer of ERBB2provided by FlyBase
    Primary source
    FLYBASE:FBgn0028397
    Locus tag
    Dmel_CG9214
    See related
    AllianceGenome:FB:FBgn0028397
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9214; Dmel\CG9214
    Summary
    Predicted to enable transcription corepressor activity. Involved in long-term memory; positive regulation of protein-containing complex assembly; and protein stabilization. Located in cell body and synaptic membrane. Is expressed in Kenyon cell; adult brain; synaptic neuropil; and wing disc. Orthologous to human TOB1 (transducer of ERBB2, 1) and TOB2 (transducer of ERBB2, 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tob in Genome Data Viewer
    Location:
    14A8-14A8; 1-52 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16074717..16091495, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15968750..15985528, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene defective proboscis extension response 18 Neighboring gene nipsnap Neighboring gene mir-4958 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene disco-related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tob Regulates the Timing of Sleep Onset at Night in Drosophila. Han E, et al. J Neurosci, 2024 May 1. PMID 38485259, Free PMC Article
    2. The Role of Functional Prion-Like Proteins in the Persistence of Memory. Si K, et al. Cold Spring Harb Perspect Biol, 2016 Apr 1. PMID 27037416, Free PMC Article
    3. The Making of Long-Lasting Memories: A Fruit Fly Perspective. Roselli C, et al. Front Behav Neurosci, 2021. PMID 33859556, Free PMC Article
    4. Knockout of Drosophila RNase ZL impairs mitochondrial transcript processing, respiration and cell cycle progression. Xie X, et al. Nucleic Acids Res, 2015 Dec 2. PMID 26553808, Free PMC Article
    5. Skewing information flow through pre- and postsynaptic plasticity in the mushroom bodies of Drosophila. Pribbenow C, et al. Learn Mem, 2024 May. PMID 38876487, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tob Regulates the Timing of Sleep Onset at Night in Drosophila.
      Title: Tob Regulates the Timing of Sleep Onset at Night in Drosophila.
    2. Tob-Orb2 association is modulated by neuronal activity and Tob activity in the mushroom body is required for stable memory formation.
      Title: Contribution of Orb2A stability in regulated amyloid-like oligomerization of Drosophila Orb2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transducer of ERBB2
    Names
    CG9214-PA
    CG9214-PC
    CG9214-PE
    CG9214-PF
    Tob-PA
    Tob-PC
    Tob-PE
    Tob-PF
    transducer of Erb2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16074717..16091495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169300.3 → NP_001162771.1  transducer of ERBB2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162771.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NQY2, Q9U6U1
      Conserved Domains (1) summary
      pfam07742
      Location:1 → 112
      BTG; BTG family

    2. NM_001169301.2 → NP_001162772.1  transducer of ERBB2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162772.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U6U1, Q9VXJ9
      Conserved Domains (1) summary
      pfam07742
      Location:1 → 112
      BTG; BTG family

    3. NM_132876.5 → NP_573104.1  transducer of ERBB2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573104.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U6U1, Q9VXJ9
      Related
      FBpp0074033
      Conserved Domains (1) summary
      pfam07742
      Location:1 → 112
      BTG; BTG family

    4. NM_206760.3 → NP_996483.2  transducer of ERBB2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996483.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V4L0, Q9U6U1
      Conserved Domains (1) summary
      pfam07742
      Location:1 → 109
      BTG; BTG family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V4L0 A4V4L0
    Q6NQY2 Q6NQY2
    Q9U6U1 Q9U6U1
    Q9VXJ9 Q9VXJ9

    Gene LinkOut

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