Gapdh2 Glyceraldehyde 3 phosphate dehydrogenase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gapdh2provided by FlyBase
Official Full Name: Glyceraldehyde 3 phosphate dehydrogenase 2provided by FlyBase
Primary source: FLYBASE:FBgn0001092
Locus tag: Dmel_CG8893
See related: AllianceGenome:FB:FBgn0001092
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8893; Dmel\CG8893; dmGAPDH; GA3PDH; GADPH; GAP; Gapd; gapdh; Gapdh; GAPDH; GAPDH II; Gapdh-2; Gapdh13F; gapdh2; GAPDH2
Summary: Enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. Involved in glucose homeostasis; glyceraldehyde-3-phosphate metabolic process; and glycolytic process. Predicted to be active in cytosol. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human GAPDH (glyceraldehyde-3-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 13F17-13F17; 1-52 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (15868145..15869661)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (15762178..15763694)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	IGI Inferred from Genetic Interaction more info	PubMed
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables peptidyl-cysteine S-nitrosylase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in canonical glycolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glyceraldehyde-3-phosphate metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: glyceraldehyde 3 phosphate dehydrogenase 2

Names: CG8893-PA; CG8893-PC; G3-P dehydrogenase; GAPDH2; Gapdh2-PA; Gapdh2-PC; dehydrogenase; glyceraldehyde 3-phosphate dehydrogenase; glyceraldehyde-3-phosphate; glyceraldehyde-3-phosphate dehydrogenase

NP_001259584.1

EC 1.2.1.-

EC 1.2.1.12

NP_542445.1

EC 1.2.1.-

EC 1.2.1.12

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

15868145..15869661

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080714.4 → NP_542445.1 glyceraldehyde 3 phosphate dehydrogenase 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_542445.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A5XCW0, P07487, Q541C2, Q9VXM7

UniProtKB/TrEMBL

M9PJN8

Related

FBpp0073922

Conserved Domains (1) summary

PLN02272
Location:2 → 328

PLN02272; glyceraldehyde-3-phosphate dehydrogenase
NM_001272655.1 → NP_001259584.1 glyceraldehyde 3 phosphate dehydrogenase 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259584.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A5XCW0, P07487, Q541C2, Q9VXM7

UniProtKB/TrEMBL

M9PJN8

Conserved Domains (1) summary

PLN02272
Location:2 → 328

PLN02272; glyceraldehyde-3-phosphate dehydrogenase