U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Ubr3 Ubr3 ubiquitin ligase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31713, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ubr3provided by FlyBase
    Official Full Name
    Ubr3 ubiquitin ligaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260970
    Locus tag
    Dmel_CG42593
    See related
    AllianceGenome:FB:FBgn0260970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1530; CG1531; CG42593; Dmel\CG42593; ubr3; UBR3
    Old locus tag
    Dmel_CG1530; Dmel_CG1531
    Summary
    Enables ubiquitin protein ligase activity. Involved in several processes, including positive regulation of smoothened signaling pathway; protein ubiquitination; and sensory perception of sound. Located in cytosol. Is active in neuronal cell body. Is expressed in several structures, including Johnston organ; eye disc; eye disc morphogenetic furrow; scolopidial cilium; and segment of antenna. Orthologous to human UBR3 (ubiquitin protein ligase E3 component n-recognin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ubr3 in Genome Data Viewer
    Location:
    7C8-7D1; 1-21 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7935896..7953883)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7829929..7847916)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ribosomal protein S14a Neighboring gene Ribosomal protein S14b Neighboring gene orion Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45620 Neighboring gene swiss cheese

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning. Ray S, et al. Elife, 2019 Mar 21. PMID 30896406, Free PMC Article
    2. Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila. Huang Q, et al. Cell Death Differ, 2014 Dec. PMID 25146930, Free PMC Article
    3. Pri sORF peptides induce selective proteasome-mediated protein processing. Zanet J, et al. Science, 2015 Sep 18. PMID 26383956
    4. Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis. Bohère J, et al. Nat Commun, 2018 Nov 30. PMID 30504772, Free PMC Article
    5. Pri peptides temporally coordinate transcriptional programs during epidermal differentiation. Gallois M, et al. Sci Adv, 2024 Feb 9. PMID 38335295, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here, the authors show that a molecular complex identified in Drosophila epidermal differentiation, comprising Mlpt peptides, ubiquitin-ligase Ubr3 and transcription factor Shavenbaby (Svb), represents an ancient developmental module required for early insect embryo patterning.
      Title: The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning.
    2. Ubr3 negatively regulates the mono-ubiquitination of non-muscle Myosin II, a protein associated with hearing loss in humans.
      Title: The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals.
    3. We identified Ubr3, an E3 ubiquitin ligase, as a novel, positive regulator of Hh signaling in Drosophila and vertebrates. Hh signaling regulates the Ubr3-mediated poly-ubiquitination and degradation of Cos2, a central component of Hh signaling. In developing Drosophila eye discs, loss of ubr3 leads to a delayed differentiation of photoreceptors and a reduction in Hh signaling.
      Title: Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination.
    4. Ubr3 interacts with DIAP1 and positively regulates DIAP1 activity, possibly by maintaining its active conformation in the apoptosis pathway.
      Title: Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuronal cell body IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Ubr3 ubiquitin ligase
    Names
    CG42593-PA
    CG42593-PB
    CG42593-PC
    Ubr3-PA
    Ubr3-PB
    Ubr3-PC

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7935896..7953883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132200.4 → NP_572428.3  Ubr3 ubiquitin ligase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572428.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PGM3, Q9W3M3
      Conserved Domains (3) summary
      pfam02207
      Location:224 → 291
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      cd16483
      Location:1513 → 1651
      RING-H2_UBR3; RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-3 (UBR3) and similar proteins
      cl25742
      Location:1413 → 1486
      ERM; Ezrin/radixin/moesin family

    2. NM_001272388.1 → NP_001259317.1  Ubr3 ubiquitin ligase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259317.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDZ8
      Conserved Domains (2) summary
      pfam02050
      Location:1410 → 1477
      FliJ; Flagellar FliJ protein
      pfam02207
      Location:224 → 291
      zf-UBR; Putative zinc finger in N-recognin (UBR box)

    3. NM_001272389.1 → NP_001259318.1  Ubr3 ubiquitin ligase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259318.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W3M3
      Conserved Domains (2) summary
      pfam02050
      Location:1410 → 1477
      FliJ; Flagellar FliJ protein
      pfam02207
      Location:224 → 291
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PDZ8 M9PDZ8
    Q9W3M3.4 Q9W3M3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools