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    Alms1a Alstrom syndrome 1a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31393, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Alms1aprovided by FlyBase
    Official Full Name
    Alstrom syndrome 1aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025388
    Locus tag
    Dmel_CG12179
    See related
    AllianceGenome:FB:FBgn0025388
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alms1a; CG12179; Dmel\CG12179; EG:66A1.2
    Summary
    Enables kinase binding activity and kinesin binding activity. Involved in male germ-line stem cell asymmetric division; positive regulation of centriole replication; and positive regulation of centrosome duplication. Colocalizes with centriole. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Alms1a in Genome Data Viewer
    Location:
    4C10-4C10; 1-8 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4631052..4636004, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4525085..4530037, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene pebbled Neighboring gene Alstrom syndrome 1b Neighboring gene partner of numb Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alstrom syndrome gene is a stem-cell-specific regulator of centriole duplication in the Drosophila testis. Chen C, et al. Elife, 2020 Sep 23. PMID 32965218, Free PMC Article
    2. Sex-Specific Transcript Diversity in the Fly Head Is Established during Pupal Stages and Adulthood and Is Largely Independent of the Mating Process and the Germline. Mohr C, et al. Sex Dev, 2017. PMID 28273663
    3. Evolution of alternative splicing in newly evolved genes of Drosophila. Zhan Z, et al. Gene, 2011 Jan 1. PMID 20851753
    4. Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. Crawford ED, et al. Cell Death Differ, 2012 Dec. PMID 22918439, Free PMC Article
    5. Tissue-specific (ts)CRISPR as an efficient strategy for in vivo screening in Drosophila. Meltzer H, et al. Nat Commun, 2019 May 8. PMID 31068592, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables kinesin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in male germ-line stem cell asymmetric division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of centriole replication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alstrom syndrome 1a
    Names
    Alms1a-PC
    Alms1a-PD
    CG12179-PC
    CG12179-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4631052..4636004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167011.4 → NP_726937.3  alstrom syndrome 1a, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726937.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5BI31, Q9W4I8, Q9W4I9
      UniProtKB/TrEMBL
      O77273
      Conserved Domains (2) summary
      PTZ00121
      Location:457 → 587
      PTZ00121; MAEBL; Provisional
      pfam15309
      Location:1190 → 1309
      ALMS_motif; ALMS motif

    2. NM_131947.4 → NP_572175.3  alstrom syndrome 1a, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572175.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5BI31, Q9W4I8, Q9W4I9
      UniProtKB/TrEMBL
      O77273
      Conserved Domains (2) summary
      PTZ00121
      Location:457 → 587
      PTZ00121; MAEBL; Provisional
      pfam15309
      Location:1190 → 1309
      ALMS_motif; ALMS motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77273 O77273
    Q5BI31.1 Q5BI31

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