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    Abhd10 abhydrolase domain containing 10 [ Mus musculus (house mouse) ]

    Gene ID: 213012, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Abhd10provided by MGI
    Official Full Name
    abhydrolase domain containing 10provided by MGI
    Primary source
    MGI:MGI:2442422
    See related
    Ensembl:ENSMUSG00000033157 AllianceGenome:MGI:2442422
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a mitochondrially-localized enzyme that acts as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There are two pseudogenes for this gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 7.3), CNS E18 (RPKM 7.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Abhd10 in Genome Data Viewer
    Location:
    16 B5; 16 30.04 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (45550088..45563355, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (45729725..45742955, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40918 Neighboring gene transmembrane serine protease 7 Neighboring gene STARR-seq mESC enhancer starr_40919 Neighboring gene STARR-seq mESC enhancer starr_40920 Neighboring gene transgelin 3 Neighboring gene STARR-seq mESC enhancer starr_40921 Neighboring gene pleckstrin homology like domain, family B, member 2 Neighboring gene STARR-seq mESC enhancer starr_40922 Neighboring gene predicted gene 15638 Neighboring gene phosphatidylinositol-specific phospholipase C, X domain containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:46006394-46006690 Neighboring gene STARR-positive B cell enhancer ABC_E4173

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis in alcoholic liver disease. Li TZ, et al. Commun Biol, 2023 Jul 3. PMID 37400491, Free PMC Article
    2. ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import. Li Q, et al. Proc Natl Acad Sci U S A, 2010 Dec 7. PMID 21078990, Free PMC Article
    3. ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5. Cao Y, et al. Nat Chem Biol, 2019 Dec. PMID 31740833, Free PMC Article
    4. Human α/β hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver. Iwamura A, et al. J Biol Chem, 2012 Mar 16. PMID 22294686, Free PMC Article
    5. MiR-19b-3p regulated by BC002059/ABHD10 axis promotes cell apoptosis in myocardial infarction. Liao B, et al. Biol Direct, 2022 Aug 18. PMID 35978367, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis in alcoholic liver disease.
      Title: The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis in alcoholic liver disease.
    2. MiR-19b-3p regulated by BC002059/ABHD10 axis promotes cell apoptosis in myocardial infarction.
      Title: MiR-19b-3p regulated by BC002059/ABHD10 axis promotes cell apoptosis in myocardial infarction.
    3. mitochondrial localization of rat Abhd10
      Title: ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import.
    4. identification of human ABHD10, which is responsible for AcMPAG deglucuronidation in the liver
      Title: Human α/β hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mycophenolic acid acyl-glucuronide esterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables palmitoyl-(protein) hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl deglucuronidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein depalmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein depalmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyl-protein thioesterase ABHD10, mitochondrial
    Names
    abhydrolase domain-containing protein 10, mitochondrial
    acyl-protein thioesterase ABHD10
    alpha/beta hydrolase domain-containing protein 10, mitochondrial
    mycophenolic acid acyl-glucuronide esterase, mitochondrial
    NP_001258999.1
    NP_001371150.1
    NP_001371152.1
    NP_766099.3
    XP_036015762.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001272070.1 → NP_001258999.1  palmitoyl-protein thioesterase ABHD10, mitochondrial isoform 2 precursor

      See identical proteins and their annotated locations for NP_001258999.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate exon structure in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK084998, BQ175828, BY281009
      UniProtKB/Swiss-Prot
      Q6PE15
      Conserved Domains (2) summary
      COG0596
      Location:56 → 268
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam12695
      Location:68 → 264
      Abhydrolase_5; Alpha/beta hydrolase family

    2. NM_001384221.1 → NP_001371150.1  palmitoyl-protein thioesterase ABHD10, mitochondrial isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC166572
      Conserved Domains (1) summary
      COG0596
      Location:56 → 282
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    3. NM_001384223.1 → NP_001371152.1  palmitoyl-protein thioesterase ABHD10, mitochondrial isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC166572
      Conserved Domains (1) summary
      COG0596
      Location:56 → 282
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    4. NM_172511.4 → NP_766099.3  palmitoyl-protein thioesterase ABHD10, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_766099.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC166572, AK052670, BC027656, BQ175828, BY281009
      Consensus CDS
      CCDS28201.1
      UniProtKB/Swiss-Prot
      Q3TMB4, Q6PE15, Q8C3S8, Q8C724, Q8K188
      Related
      ENSMUSP00000065282.7, ENSMUST00000066983.13
      Conserved Domains (2) summary
      pfam12695
      Location:68 → 270
      Abhydrolase_5; Alpha/beta hydrolase family
      pfam12697
      Location:69 → 277
      Abhydrolase_6; Alpha/beta hydrolase family

    RNA

    1. NR_073572.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an internal exon and contains an alternate exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC166572, AK052670, BC027656, BQ175828, BY281009, CX237340

    2. NR_169116.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC166572

    3. NR_169117.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC166572

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      45550088..45563355 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159869.1 → XP_036015762.1  palmitoyl-protein thioesterase ABHD10, mitochondrial isoform X1

      Conserved Domains (1) summary
      COG0596
      Location:56 → 171
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PE15.1 GenPept UniProtKB/Swiss-Prot:Q6PE15

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