Gipr gastric inhibitory polypeptide receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Giprprovided by RGD
Official Full Name: gastric inhibitory polypeptide receptorprovided by RGD
Primary source: RGD:2689
See related: EnsemblRapid:ENSRNOG00000015860 AllianceGenome:RGD:2689
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gippr; RATGIPPR
Summary: Enables gastric inhibitory peptide receptor activity and peptide hormone binding activity. Involved in several processes, including desensitization of G protein-coupled receptor signaling pathway; gastric inhibitory peptide signaling pathway; and positive regulation of insulin secretion. Predicted to be active in plasma membrane. Used to study type 2 diabetes mellitus. Biomarker of hyperglycemia. Human ortholog(s) of this gene implicated in cardiovascular system disease; diabetes mellitus; and obesity. Orthologous to human GIPR (gastric inhibitory polypeptide receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 16.0), Thymus (RPKM 6.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (87932316..87956084, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (78804287..78814462, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (80063047..80073223, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disbalance of the Duodenal Epithelial Cell Turnover and Apoptosis Accompanies Insensitivity of Intestinal Redox Homeostasis to Inhibition of the Brain Glucose-Dependent Insulinotropic Polypeptide Receptors in a Rat Model of Sporadic Alzheimer's Disease.
Title: Disbalance of the Duodenal Epithelial Cell Turnover and Apoptosis Accompanies Insensitivity of Intestinal Redox Homeostasis to Inhibition of the Brain Glucose-Dependent Insulinotropic Polypeptide Receptors in a Rat Model of Sporadic Alzheimer's Disease.
GIP-GIPR promotes neurite outgrowth of cortical neurons in Akt dependent manner.
Title: GIP-GIPR promotes neurite outgrowth of cortical neurons in Akt dependent manner.
Gipr is expressed in healthy arteries, predominantly in endothelial cells.
Title: Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.
glucose-dependent insulinotropic polypeptide and Glucose-dependent insulinotropic polypeptide receptors expression in the rat major salivary glands, as well as its variation in the rat SMG during the growth period
Title: Expression of glucose-dependent insulinotropic polypeptide and its receptor in the rat major salivary glands.
Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor.
Title: Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor.
Results indicate that Pax6 acts on the regulation of glucagon secretion at least through the transcriptional control of GCK, GPR40, and GIPR.
Title: Pax6 is a key component of regulated glucagon secretion.
Disruption of a signaling pathway may account for the lowered beta-cell GIP-R expression and resulting GIP resistance in type 2 diabetes.
Title: Physiologic and pharmacologic modulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta-cells by peroxisome proliferator-activated receptor (PPAR)-gamma signaling: possible mechanism for the GIP resistance in type 2 diabetes.
These findings support the proposal that GIP receptor down-regulation in rodent T2DM is secondary to chronic hyperglycemia and that normalization of glycemia can restore GIP sensitivity.
Title: Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat.
GIP-R is ubiquitinated, resulting in downregulation of the actions of GIP.
Title: Ubiquitination is involved in glucose-mediated downregulation of GIP receptors in islets.
A novel pathway for downregulation of GIP receptor expression in Pancreatic beta Cells.
Title: A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

D1Wox30 (e-PCR)
- UniSTS:118101

Gipr (e-PCR), detects polymorphism
- UniSTS:548042

RH144450 (e-PCR)
- UniSTS:233695

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables gastric inhibitory peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables gastric inhibitory peptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables gastric inhibitory peptide receptor activity	IEA Inferred from Electronic Annotation more info
enables gastric inhibitory peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables glucagon family peptide binding	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IPI Inferred from Physical Interaction more info	PubMed
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in desensitization of G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within endocrine pancreas development	ISO Inferred from Sequence Orthology more info
involved_in gastric inhibitory peptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in gastric inhibitory peptide signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastric inhibitory peptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in response to axon injury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to calcium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gastric inhibitory polypeptide receptor

Names: GIP-R; gastric inhibitory peptide receptor; glucose-dependent insulinotropic polypeptide receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012714.2 → NP_036846.1 gastric inhibitory polypeptide receptor precursor

See identical proteins and their annotated locations for NP_036846.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P43219

UniProtKB/TrEMBL

A0A8I5ZT57, A6J8K3

Related

ENSRNOP00000021456.1, ENSRNOT00000021456.4

Conserved Domains (2) summary

pfam00002
Location:131 → 385

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:55 → 118

HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

87932316..87956084 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281146.1 → XP_063137216.1 gastric inhibitory polypeptide receptor isoform X1

UniProtKB/Swiss-Prot

P43219

UniProtKB/TrEMBL

A0A8I5ZT57, A6J8K3