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    MAPKKK6 mitogen-activated protein kinase kinase kinase 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819989, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MAPKKK6
    Official Full Name
    mitogen-activated protein kinase kinase kinase 6
    Primary source
    TAIR:AT3G07980
    Locus tag
    AT3G07980
    See related
    Araport:AT3G07980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MAP3K EPSILON PROTEIN KINASE 2; MAP3KE2; mitogen-activated protein kinase kinase kinase 6
    Summary
    MAP3K epsilon protein kinase 2 is functionally redundant with MAP3Ke1. Required for pollen development but not essential.
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    Genomic context

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    See MAPKKK6 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    25
    Sequence:
    Chromosome: 3; NC_003074.8 (2543603..2551360, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene rhomboid protein-like protein Neighboring gene Phosphatidylinositol-4-phosphate 5-kinase family protein Neighboring gene Pectin lyase-like superfamily protein Neighboring gene serine carboxypeptidase-like 27 Neighboring gene ncRNA Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The protein kinase genes MAP3K epsilon 1 and MAP3K epsilon 2 are required for pollen viability in Arabidopsis thaliana. Chaiwongsar S, et al. Plant J, 2006 Oct. PMID 16965555
    2. AtSGP1, AtSGP2 and MAP4K alpha are nucleolar plant proteins that can complement fission yeast mutants lacking a functional SIN pathway. Champion A, et al. J Cell Sci, 2004 Aug 15. PMID 15292395
    3. Large-scale characterization of integral proteins from Arabidopsis vacuolar membrane by two-dimensional liquid chromatography. Szponarski W, et al. Proteomics, 2004 Feb. PMID 14760709
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAP3Kepsilon2 is required for pollen viability in Arabidopsis.
      Title: The protein kinase genes MAP3K epsilon 1 and MAP3K epsilon 2 are required for pollen viability in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001337757.1
    NM_111677.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within plasma membrane organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 6
    NP_187455.1
    • mitogen-activated protein kinase kinase kinase 6 (MAPKKK6); FUNCTIONS IN: protein serine/threonine kinase activity, binding, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: plasma membrane organization, pollen development; LOCATED IN: vacuole; EXPRESSED IN: male gametophyte, pollen tube; EXPRESSED DURING: M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: mitogen-activated protein kinase kinase kinase 7 (TAIR:AT3G13530.1); Has 136121 Blast hits to 133731 proteins in 5126 species: Archae - 192; Bacteria - 15089; Metazoa - 51503; Fungi - 13384; Plants - 33405; Viruses - 666; Other Eukaryotes - 21882 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2543603..2551360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001337756.1 → NP_001326459.1  mitogen-activated protein kinase kinase kinase 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VGC1, A0A1I9LPC2, A0A5S9XAF7
      Conserved Domains (1) summary
      cd06627
      Location:19 → 274
      STKc_Cdc7_like; Catalytic domain of Cell division control protein 7-like Serine/Threonine Kinases

    2. NM_111677.4 → NP_187455.1  mitogen-activated protein kinase kinase kinase 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187455.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SFB6
      UniProtKB/TrEMBL
      A0A178VGC1, A0A5S9XAF7
      Conserved Domains (1) summary
      cd06627
      Location:19 → 274
      STKc_Cdc7_like; Catalytic domain of Cell division control protein 7-like Serine/Threonine Kinases

    3. NM_001337757.1 → NP_001326460.1  mitogen-activated protein kinase kinase kinase 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VGC1, A0A1I9LPC3, A0A5S9XAF7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SFB6.1

    Gene LinkOut

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