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    LAF3 Amidohydrolase family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824751, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LAF3
    Official Full Name
    Amidohydrolase family
    Primary source
    TAIR:AT3G55850
    Locus tag
    AT3G55850
    See related
    Araport:AT3G55850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    LAF3 ISF1; LAF3 ISF2; LAF3 ISOFORM 2; LONG AFTER FAR-RED 3; LONG AFTER FAR-RED 3 ISOFORM 1
    Summary
    Encodes a product that might regulate nucleo-cytoplasmic trafficking of an intermediate(s) involved in phyA signal transduction. Differs from isoform 2 only in the first few N-terminal amino acids.
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    Genomic context

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    See LAF3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Sequence:
    Chromosome: 3; NC_003074.8 (20721602..20725893, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Fasciclin-like arabinogalactan family protein Neighboring gene Nucleotide-diphospho-sugar transferases superfamily protein Neighboring gene Hs1pro-1 protein Neighboring gene uncharacterized protein Neighboring gene ADC synthase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LAF3, a novel factor required for normal phytochrome A signaling. Hare PD, et al. Plant Physiol, 2003 Dec. PMID 14645728, Free PMC Article
    2. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article
    3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001339748.1
    NM_001339749.1
    NM_001339750.1
    NM_001339751.1
    NM_115443.4
    NM_202716.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in de-etiolation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to far red light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to far red light IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in seed germination IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Amidohydrolase family
    NP_001319763.1
    • LONG AFTER FAR-RED 3 (LAF3); FUNCTIONS IN: hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; INVOLVED IN: biological_process unknown; LOCATED IN: perinuclear region of cytoplasm; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Amidohydrolase 3 (InterPro:IPR013108), Metal-dependent hydrolase, composite domain (InterPro:IPR011059); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_567027.2
    • LAF3 ISOFORM 2 (LAF3 ISF2); FUNCTIONS IN: hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; INVOLVED IN: biological_process unknown; LOCATED IN: perinuclear region of cytoplasm; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Amidohydrolase 3 (InterPro:IPR013108), Metal-dependent hydrolase, composite domain (InterPro:IPR011059); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20721602..20725893 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001339748.1 → NP_001319763.1  Amidohydrolase family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EX26, F4IY41
      Conserved Domains (2) summary
      cd01300
      Location:1 → 432
      YtcJ_like; YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling.
      cl00281
      Location:406 → 460
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    2. NM_001339750.1 → NP_001326018.1  Amidohydrolase family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LN02
      Conserved Domains (2) summary
      cd01300
      Location:9 → 415
      YtcJ_like; YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling.
      cl00281
      Location:389 → 443
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    3. NM_001339749.1 → NP_001326016.1  Amidohydrolase family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LMZ9

    4. NM_202716.3 → NP_974445.2  Amidohydrolase family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974445.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LN01, F4IY42, Q7Y048, Q7Y049, Q93ZE1, Q9LY60
      UniProtKB/TrEMBL
      A0A7G2EX26
      Conserved Domains (2) summary
      cd01300
      Location:71 → 554
      YtcJ_like; YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling.
      cl00281
      Location:528 → 582
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    5. NM_115443.4 → NP_567027.2  Amidohydrolase family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567027.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XLA5
      Conserved Domains (2) summary
      cd01300
      Location:64 → 547
      YtcJ_like; YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling.
      cl00281
      Location:521 → 575
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    6. NM_001339751.1 → NP_001326017.1  Amidohydrolase family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XLA5
      Conserved Domains (2) summary
      cd01300
      Location:64 → 547
      YtcJ_like; YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling.
      cl00281
      Location:521 → 575
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A1I9LN01.1

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