CDKN1A cyclin dependent kinase inhibitor 1A [Homo sapiens (human)] - Gene

Summary

Official Symbol: CDKN1Aprovided by HGNC
Official Full Name: cyclin dependent kinase inhibitor 1Aprovided by HGNC
Primary source: HGNC:HGNC:1784
See related: Ensembl:ENSG00000124762 MIM:116899; AllianceGenome:HGNC:1784
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1
Summary: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015]
Expression: Ubiquitous expression in colon (RPKM 71.4), gall bladder (RPKM 68.8) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p21.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (36676463..36687332)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (36497108..36508013)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (36644240..36655109)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM40 interacts with ROCK1 directly and inhibits colorectal cancer cell proliferation through the c-Myc/p21 axis.
Title: TRIM40 interacts with ROCK1 directly and inhibits colorectal cancer cell proliferation through the c-Myc/p21 axis.
HIV-1 controllers exhibit an enhanced antiretroviral innate state characterised by overexpression of p21 and MCPIP1 and silencing of ERVK-6 RNA expression.
Title: HIV-1 controllers exhibit an enhanced antiretroviral innate state characterised by overexpression of p21 and MCPIP1 and silencing of ERVK-6 RNA expression.
Transcriptome analysis of polyploid giant cancer cells and their progeny reveals a functional role for p21 in polyploidization and depolyploidization.
Title: Transcriptome analysis of polyploid giant cancer cells and their progeny reveals a functional role for p21 in polyploidization and depolyploidization.
ATM-Mediated translocation of RanBPM regulates DNA damage response by stabilizing p21 in non-small cell lung cancer cells.
Title: ATM-Mediated translocation of RanBPM regulates DNA damage response by stabilizing p21 in non-small cell lung cancer cells.
Deoxyribonuclease 1-like 3 inhibits colorectal malignancy through antagonizing NEDD4-triggered CDKN1A ubiquitination.
Title: Deoxyribonuclease 1-like 3 inhibits colorectal malignancy through antagonizing NEDD4-triggered CDKN1A ubiquitination.
p21 Prevents the Exhaustion of CD4[+] T Cells Within the Antitumor Immune Response Against Colorectal Cancer.
Title: p21 Prevents the Exhaustion of CD4(+) T Cells Within the Antitumor Immune Response Against Colorectal Cancer.
CLIC3 interacts with NAT10 to inhibit N4-acetylcytidine modification of p21 mRNA and promote bladder cancer progression.
Title: CLIC3 interacts with NAT10 to inhibit N4-acetylcytidine modification of p21 mRNA and promote bladder cancer progression.
CDKN1A/p21 in Breast Cancer: Part of the Problem, or Part of the Solution?
Title: CDKN1A/p21 in Breast Cancer: Part of the Problem, or Part of the Solution?
Long non-coding RNA generated from CDKN1A gene by alternative polyadenylation regulates p21 expression during DNA damage response.
Title: Long non-coding RNA generated from CDKN1A gene by alternative polyadenylation regulates p21 expression during DNA damage response.
A candidate prognostic biomarker: TFEB inhibits tumor progression via elevating CDKN1A in bladder cancer.
Title: A candidate prognostic biomarker: TFEB inhibits tumor progression via elevating CDKN1A in bladder cancer.

Submit: New GeneRIF Correction See all GeneRIFs (1476)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. EBI GWAS Catalog EBI GWAS CatalogPubMed
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians. EBI GWAS Catalog EBI GWAS CatalogPubMed
Several common variants modulate heart rate, PR interval and QRS duration. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infection in CD4+ T cells induces higher expression of CDKN1A (p21)	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of cyclin-dependent kinase inhibitor 1A (CDKN1A; p21; Cip1) in human B cells	PubMed
	env	HIV-1 gp120 induces NF-kappaB activation and increases p21(cip1/waf1) and p27(kip1) protein levels in human mesangial cells	PubMed
Nef	nef	HIV-1 Nef upregulates the expression of p21/WAF1 protein in human mesenchymal stem cells	PubMed
Tat	tat	HIV-1 Tat upregulates the expression of p21/WAF1 protein in human mesenchymal stem cells	PubMed
	tat	Treatment with HIV-Tat and morphine activates extracellular signal-regulated kinase-1/2 (ERK1/2), upregulates p53 and p21 levels, and downregulates cyclin D1 and Akt levels in human fetal brain-derived neural precursor cells	PubMed
	tat	HIV-1 Tat inhibits SIRT1 and increases acetylation of p53, which leads to activation of p21 and BAX in HeLa-CD4+ cells	PubMed
	tat	A p53 fusion protein with the HIV-1 Tat basic domain at its N terminus activates the expression of p21and downregulates the levels of caspase-3 and Bcl-2	PubMed
Vif	vif	HIV-1 Vif upregulates the expression of cyclin-dependent kinase inhibitor 1A (CDKN1A, p21, Cip1) in Vif-expression T cells	PubMed
Vpr	vpr	Activation of p21/Waf1/Cip1 by HIV-1 Vpr appears to be dependent upon p53	PubMed
	vpr	COUP-TF-interacting protein 2 (CTIP2) abolishes Vpr-mediated stimulation of p21 by cooperating with SUV39H1 and HDAC1/HDAC2 to silence the p21 gene transcription	PubMed
	vpr	Results from GST pull-down assays show the association of Vpr with p53 in extracts containing Sp1, suggesting the physical interaction of Vpr with Sp1 and p53 could modulate transcriptional activity of p21	PubMed
	vpr	HIV-1 Vpr activates promoter activity of p21/Cip1/Waf1 through the GC-rich region located between nucleotides -84 and -74 in a manner that requires cooperativity of Sp1, which binds to the DNA sequence spanning -84 to -74	PubMed
	vpr	HIV-1 Vpr activates the expression and transcription of the cyclin-dependent kinase inhibitor p21/Waf1/Cip1, an inhibitor of the G1 and G2/M phase transitions in T lymphoid and myeloid cells	PubMed
integrase	gag-pol	Cyclin-dependent kinase inhibitor (CKI) p21 (Waf1/Cip1/Sdi1) blocks viral infection by complexing with HIV-1 integrase and aborting chromosomal integration in hematopoietic stem cells	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6S2036 (e-PCR)
- UniSTS:20745

GDB:606724 (e-PCR)
- UniSTS:158230

GDB:607527 (e-PCR)
- UniSTS:158231

PMC310739P1 (e-PCR)
- UniSTS:272664

PMC29718P1 (e-PCR)
- UniSTS:272454

PMC29718P2 (e-PCR)
- UniSTS:272455

PMC133799P1 (e-PCR)
- UniSTS:270664

CDKN1A_13 (e-PCR)
- UniSTS:277092

PMC140670P2 (e-PCR)
- UniSTS:270958

PMC25807P2 (e-PCR)
- UniSTS:272287

D20S716E (e-PCR)
- UniSTS:153810

PMC150720P1 (e-PCR)
- UniSTS:271069

RH70551 (e-PCR)
- UniSTS:5860

WI-7311 (e-PCR)
- UniSTS:11006

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cyclin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables cyclin-dependent protein kinase activating kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular function activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables molecular function inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein sequestering activity	EXP Inferred from Experiment more info	PubMed
enables protein sequestering activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	TAS Traceable Author Statement more info
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IEA Inferred from Electronic Annotation more info
involved_in G1/S transition of mitotic cell cycle	TAS Traceable Author Statement more info
involved_in Ras protein signal transduction	IEP Inferred from Expression Pattern more info	PubMed
involved_in animal organ regeneration	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV-B	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to amino acid starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to gamma radiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to heat	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ionizing radiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cellular senescence	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular senescence	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular senescence	TAS Traceable Author Statement more info
involved_in fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
involved_in intestinal epithelial cell maturation	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in mitotic G2 DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cardiac muscle tissue regeneration	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cyclin-dependent protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oncogene-induced cell senescence	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of B cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA replication	TAS Traceable Author Statement more info
involved_in positive regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of programmed cell death	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of cell cycle G1/S phase transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed
involved_in replicative senescence	IEA Inferred from Electronic Annotation more info
involved_in response to X-ray	IEA Inferred from Electronic Annotation more info
involved_in response to aldosterone	IEA Inferred from Electronic Annotation more info
involved_in response to arsenic-containing substance	IEA Inferred from Electronic Annotation more info
involved_in response to corticosterone	IEA Inferred from Electronic Annotation more info
involved_in response to hyperoxia	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in stress-induced premature senescence	TAS Traceable Author Statement more info	PubMed
involved_in tissue regeneration	IEA Inferred from Electronic Annotation more info
involved_in wound healing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of PCNA-p21 complex	IDA Inferred from Direct Assay more info	PubMed
part_of PCNA-p21 complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of PCNA-p21 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin-dependent protein kinase holoenzyme complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cyclin-dependent kinase inhibitor 1

Names: CDK-interacting protein 1; CDK-interaction protein 1; DNA synthesis inhibitor; cyclin-dependent kinase inhibitor 1A (p21, Cip1); melanoma differentiation associated protein 6; wild-type p53-activated fragment 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009364.2 RefSeqGene

Range

7253..15871

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000389.5 → NP_000380.1 cyclin-dependent kinase inhibitor 1 isoform 1

See identical proteins and their annotated locations for NP_000380.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, lacks an in-frame portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. The resulting isoform (1) has a shorter N-terminus, compared to isoform 2. Variants 1, 2, 4, 5, and 10 all encode the same isoform (1).

Source sequence(s)

Z85996

Consensus CDS

CCDS4824.1

UniProtKB/Swiss-Prot

P38936, Q14010, Q6FI05, Q9BUT4

UniProtKB/TrEMBL

Q59ED0

Related

ENSP00000244741.6, ENST00000244741.10

Conserved Domains (1) summary

pfam02234
Location:21 → 66

CDI; Cyclin-dependent kinase inhibitor
NM_001220777.2 → NP_001207706.1 cyclin-dependent kinase inhibitor 1 isoform 1

See identical proteins and their annotated locations for NP_001207706.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, lacks an in-frame portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. The resulting isoform (1) has a shorter N-terminus, compared to isoform 2. Variants 1, 2, 4, 5, and 10 all encode the same isoform (1).

Source sequence(s)

Z85996

Consensus CDS

CCDS4824.1

UniProtKB/Swiss-Prot

P38936, Q14010, Q6FI05, Q9BUT4

UniProtKB/TrEMBL

Q59ED0

Related

ENSP00000482768.1, ENST00000615513.4

Conserved Domains (1) summary

pfam02234
Location:21 → 66

CDI; Cyclin-dependent kinase inhibitor
NM_001220778.2 → NP_001207707.1 cyclin-dependent kinase inhibitor 1 isoform 1

See identical proteins and their annotated locations for NP_001207707.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks an in-frame portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. The resulting isoform (1) has a shorter N-terminus, compared to isoform 2. Variants 1, 2, 4, 5, and 10 all encode the same isoform (1).

Source sequence(s)

Z85996

Consensus CDS

CCDS4824.1

UniProtKB/Swiss-Prot

P38936, Q14010, Q6FI05, Q9BUT4

UniProtKB/TrEMBL

Q59ED0

Related

ENSP00000384849.1, ENST00000405375.5

Conserved Domains (1) summary

pfam02234
Location:21 → 66

CDI; Cyclin-dependent kinase inhibitor
NM_001291549.3 → NP_001278478.1 cyclin-dependent kinase inhibitor 1 isoform 2

See identical proteins and their annotated locations for NP_001278478.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) encodes the longest isoform (2). Variants 3 and 6 both encode the same isoform (2).

Source sequence(s)

Z85996

UniProtKB/TrEMBL

B4DQP9

Conserved Domains (1) summary

pfam02234
Location:55 → 100

CDI; Cyclin-dependent kinase inhibitor
NM_001374509.1 → NP_001361438.1 cyclin-dependent kinase inhibitor 1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (6), as well as variant 3, encodes isoform 2.

Source sequence(s)

Z85996

UniProtKB/TrEMBL

B4DQP9

Conserved Domains (1) summary

pfam02234
Location:55 → 100

CDI; Cyclin-dependent kinase inhibitor
NM_001374510.1 → NP_001361439.1 cyclin-dependent kinase inhibitor 1 isoform 3

Status: REVIEWED

Source sequence(s)

Z85996

UniProtKB/TrEMBL

Q59ED0

Conserved Domains (1) summary

pfam02234
Location:34 → 79

CDI; Cyclin-dependent kinase inhibitor
NM_001374511.1 → NP_001361440.1 cyclin-dependent kinase inhibitor 1 isoform 4

Status: REVIEWED

Source sequence(s)

Z85996

UniProtKB/TrEMBL

Q59ED0

Conserved Domains (1) summary

pfam02234
Location:21 → 66

CDI; Cyclin-dependent kinase inhibitor
NM_001374512.1 → NP_001361441.1 cyclin-dependent kinase inhibitor 1 isoform 5

Status: REVIEWED

Source sequence(s)

Z85996

UniProtKB/TrEMBL

Q96LE1

Conserved Domains (1) summary

pfam02234
Location:21 → 66

CDI; Cyclin-dependent kinase inhibitor
NM_001374513.1 → NP_001361442.1 cyclin-dependent kinase inhibitor 1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (10), as well as variants 1, 2, 4, and 5, encodes isoform 1.

Source sequence(s)

Z85996

Consensus CDS

CCDS4824.1

UniProtKB/Swiss-Prot

P38936, Q14010, Q6FI05, Q9BUT4

UniProtKB/TrEMBL

Q59ED0

Conserved Domains (1) summary

pfam02234
Location:21 → 66

CDI; Cyclin-dependent kinase inhibitor
NM_078467.3 → NP_510867.1 cyclin-dependent kinase inhibitor 1 isoform 1

See identical proteins and their annotated locations for NP_510867.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks an in-frame portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. The resulting isoform (1) has a shorter N-terminus, compared to isoform 2. Variants 1, 2, 4, 5, and 10 all encode the same isoform (1).

Source sequence(s)

Z85996

Consensus CDS

CCDS4824.1

UniProtKB/Swiss-Prot

P38936, Q14010, Q6FI05, Q9BUT4

UniProtKB/TrEMBL

Q59ED0

Related

ENSP00000409259.3, ENST00000448526.6

Conserved Domains (1) summary

pfam02234
Location:21 → 66

CDI; Cyclin-dependent kinase inhibitor

RNA

NR_164655.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

Z85996
NR_164656.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

Z85996

Related

ENST00000462537.3