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    arrb2b arrestin, beta 2b [ Danio rerio (zebrafish) ]

    Gene ID: 394099, updated on 4-Jan-2025

    Summary

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    Official Symbol
    arrb2bprovided by ZNC
    Official Full Name
    arrestin, beta 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1332
    See related
    Ensembl:ENSDARG00000011545 AllianceGenome:ZFIN:ZDB-GENE-040426-1332
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    arrb2; zgc:64007
    Summary
    Acts upstream of or within muscle organ development; regulation of receptor recycling; and regulation of signal transduction. Predicted to be located in cytoplasm. Is expressed in several structures, including alar plate midbrain region; axis; brain; vasculature; and ventral mesoderm. Human ortholog(s) of this gene implicated in glioblastoma; heroin dependence; nicotine dependence; and opiate dependence. Orthologous to human ARRB2 (arrestin beta 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See arrb2b in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (25920805..26005199)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (25649571..25732568)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene CD99 molecule-like 2 Neighboring gene uncharacterized LOC108190781 Neighboring gene high mobility group box 3a Neighboring gene uncharacterized LOC137496167 Neighboring gene proline, glutamate and leucine rich protein 1 Neighboring gene arachidonate 12-lipoxygenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway. Wilbanks AM, et al. Science, 2004 Dec 24. PMID 15618520
    2. β-arrestin control of late endosomal sorting facilitates decoy receptor function and chemokine gradient formation. Mahabaleshwar H, et al. Development, 2012 Aug. PMID 22791893
    3. Cone arrestin confers cone vision of high temporal resolution in zebrafish larvae. Renninger SL, et al. Eur J Neurosci, 2011 Feb. PMID 21299656
    4. Exposure of low-dose fipronil enantioselectively induced anxiety-like behavior associated with DNA methylation changes in embryonic and larval zebrafish. Qian Y, et al. Environ Pollut, 2019 Jun. PMID 30909129
    5. Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2. Burczyk M, et al. Biochemistry, 2015 Jan 27. PMID 25555130, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC64007

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of chemokine activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of receptor recycling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    arrestin, beta 2b
    Names
    ARRB2b2
    arrestin, beta 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201124.1 → NP_957418.1  arrestin, beta 2b

      See identical proteins and their annotated locations for NP_957418.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054595
      UniProtKB/TrEMBL
      A0A8M3B3X5, B2GPW5, Q7T2D2
      Related
      ENSDARP00000024694.6, ENSDART00000026295.9
      Conserved Domains (2) summary
      smart01017
      Location:194 → 349
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:19 → 175
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      25920805..26005199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222202.1 → XP_068078303.1  arrestin, beta 2b isoform X1

      UniProtKB/TrEMBL
      A0A8M3B109

    2. XM_009303041.4 → XP_009301316.1  arrestin, beta 2b isoform X2

      UniProtKB/TrEMBL
      A0A8M3AU12
      Conserved Domains (2) summary
      smart01017
      Location:194 → 334
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:19 → 175
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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