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    vamp8 vesicle-associated membrane protein 8 (endobrevin) [ Danio rerio (zebrafish) ]

    Gene ID: 327007, updated on 4-Jan-2025

    Summary

    Official Symbol
    vamp8provided by ZNC
    Official Full Name
    vesicle-associated membrane protein 8 (endobrevin)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5215
    See related
    Ensembl:ENSDARG00000024116 AllianceGenome:ZFIN:ZDB-GENE-030131-5215
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56588; wu:fa18d07
    Summary
    Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in SNARE complex assembly and mucus secretion. Predicted to act upstream of or within autophagy; defense response to virus; and vesicle-mediated transport. Predicted to be located in bounding membrane of organelle. Predicted to be part of SNARE complex. Predicted to be active in mucin granule and plasma membrane. Is expressed in otic vesicle; periderm; pharynx; pronephric duct; and sensory system. Orthologous to human VAMP8 (vesicle associated membrane protein 8). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See vamp8 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (28271412..28279364)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (27671259..27679211)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene tachykinin receptor 1a Neighboring gene non-SMC condensin I complex, subunit H Neighboring gene si:dkeyp-86b9.5 Neighboring gene vesicle-associated membrane protein 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in SNARE complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mucus secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mucin granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in zymogen granule membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    vesicle-associated membrane protein 8
    Names
    endobrevin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199759.1NP_956053.1  vesicle-associated membrane protein 8

      See identical proteins and their annotated locations for NP_956053.1

      Status: PROVISIONAL

      Source sequence(s)
      BC049333
      UniProtKB/TrEMBL
      A0A2R8QAD4, F6NUW8, Q7ZUC1
      Related
      ENSDARP00000032940.4, ENSDART00000031727.5
      Conserved Domains (2) summary
      cd15868
      Location:2185
      R-SNARE_VAMP8; SNARE motif of VAMP8
      pfam00957
      Location:1985
      Synaptobrevin; Synaptobrevin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      28271412..28279364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394578.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      140680..148844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)