U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Ackr3 atypical chemokine receptor 3 [ Mus musculus (house mouse) ]

    Gene ID: 12778, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ackr3provided by MGI
    Official Full Name
    atypical chemokine receptor 3provided by MGI
    Primary source
    MGI:MGI:109562
    See related
    Ensembl:ENSMUSG00000044337 AllianceGenome:MGI:109562
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rdc1; Cxcr7; RDC-1; CXC-R7; CXCR-7; Cmkor1
    Summary
    Predicted to enable chemokine binding activity; chemokine receptor activity; and scavenger receptor activity. Involved in oculomotor nerve development. Acts upstream of or within negative regulation of cell population proliferation and positive regulation of ERK1 and ERK2 cascade. Predicted to be located in several cellular components, including cell surface; clathrin-coated pit; and endosome. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; heart; and hemolymphoid system. Orthologous to human ACKR3 (atypical chemokine receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 169.3), heart adult (RPKM 116.2) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ackr3 in Genome Data Viewer
    Location:
    1 D; 1 45.28 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (90131702..90143446)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (90203980..90215724)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01676 Neighboring gene IQ motif containing with AAA domain 1 Neighboring gene RIKEN cDNA 4930434B07 gene Neighboring gene STARR-seq mESC enhancer starr_01677 Neighboring gene STARR-positive B cell enhancer ABC_E4333 Neighboring gene RIKEN cDNA 2700003A03 gene Neighboring gene predicted gene, 34992 Neighboring gene STARR-seq mESC enhancer starr_01681

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (19)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables C-X-C chemokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables C-X-C chemokine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables C-X-C chemokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables C-X-C chemokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables scavenger receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables scavenger receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oculomotor nerve development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in oculomotor nerve development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oculomotor nerve development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of mesenchymal stem cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mesenchymal stem cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor internalization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated pit ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    atypical chemokine receptor 3
    Names
    C-X-C chemokine receptor type 7
    G-protein coupled receptor RDC1 homolog
    chemokine (C-X-C motif) receptor 7
    chemokine orphan receptor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271607.1NP_001258536.1  atypical chemokine receptor 3

      See identical proteins and their annotated locations for NP_001258536.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC110261, AC120878
      Consensus CDS
      CCDS15152.1
      UniProtKB/Swiss-Prot
      P56485, Q91WI0
      Conserved Domains (1) summary
      cd14987
      Location:45326
      7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_007722.4NP_031748.2  atypical chemokine receptor 3

      See identical proteins and their annotated locations for NP_031748.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC110261, AK031100, BQ033958
      Consensus CDS
      CCDS15152.1
      UniProtKB/Swiss-Prot
      P56485, Q91WI0
      Related
      ENSMUSP00000069114.5, ENSMUST00000065587.5
      Conserved Domains (1) summary
      cd14987
      Location:45326
      7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      90131702..90143446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157069.1XP_036012962.1  atypical chemokine receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      P56485, Q91WI0
      Conserved Domains (1) summary
      cd14987
      Location:45326
      7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors